Faculty Profiles

Bhandari, J., Guillén-Mendoza, C., Banks, K. P., Eliaz, L., Southwell, S., Eyaa, D., … Xue, X. (2024). The molecular chaperone ALYREF promotes R-loop resolution and maintains genome stability. The Journal of Biological Chemistry, 300(12), 107996. https://doi.org/10.1016/j.jbc.2024.107996

Xue, X., Fan, J., Gallegos Elias, P. A., Zhu, X., Epps, J., Holland, K., … Zhao, X. (n.d.). Mechanism of Smc5/6-mediated protein sumoylation in genome maintenance.

Chakraborty, A., Dutta, A., Dettori, L. G., Daoud, R., Li, J., Gonzalez, L., … Feng, W. (2024). Complex interplay between FMRP and DHX9 during DNA replication stress. The Journal of Biological Chemistry, 300(1), 105572.

Marchena-Cruz, E., Camino, L. P., Bhandari, J., Silva, S., Marqueta-Gracia, J. J., Amdeen, S. A., … Aguilera, A. (2023). DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops. Cell Reports, 42(3), 112148.

Li, S., Mutchler, A., Zhu, X., So, S., Epps, J., Guan, D., … Xue, X. (2022). Multifaceted regulation of the sumoylation of the Sgs1 DNA helicase. The Journal of Biological Chemistry, 298(7), 102092. https://doi.org/10.1016/j.jbc.2022.102092

Li, S., Bonner, J. N., Wan, B., So, S., Summers, A. S., Gonzalez, L., … Zhao, X. (2021). Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes & Development, 35(3–4), 261–272. https://doi.org/10.1101/gad.344739.120

Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, S., Simonsen AKW, Viswalingam, K. S., … Lisby, M. (2020). The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells. Cell Reports, 32(1), 107849. https://doi.org/10.1016/j.celrep.2020.107849

Lisby, M., & Xue, X. (2020). Protocol for Purification of Human ZGRF1 and Its Regulatory Function on RAD51-Mediated D-Loop Formation. STAR Protocols, 1(2), 100099. https://doi.org/10.1016/j.xpro.2020.100099

Pérez-Calero, C., Bayona-Feliu, A., Xue, X., Barroso, S. I., Muñoz, S., González-Basallote, V. M., … Aguilera, A. (2020). UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide. Genes & Development, 34(13–14), 898–912. https://doi.org/10.1101/gad.336024.119

Daley, J. M., Tomimatsu, N., Hooks, G., Wang, W., Miller, A. S., Xue, X., … Sung, P. (2020). Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions. Nature Communications, 11(1), 3088. https://doi.org/10.1038/s41467-020-16903-4

Jiang, H., Xue, X., Panda, S., Kawale, A., Hooy, R. M., Liang, F., … Gekara, N. O. (2019). Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. The EMBO Journal, e102718. https://doi.org/10.15252/embj.2019102718

Xue, C., Daley, J. M., Xue, X., Steinfeld, J., Kwon, Y., Sung, P., & Greene, E. C. (2019). Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates. Nucleic Acids Research. https://doi.org/10.1093/nar/gkz810

Wang, W., Daley, J. M., Kwon, Y., Xue, X., Krasner, D. S., Miller, A. S., … others. (2018). A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1-Dna2 in long-range DNA end resection. Journal of Biological Chemistry, jbc--RA118.

Li, T., Zhao, Q., Yang, X., Chen, C., Yang, K., Wu, C., … others. (2018). Structural insight into the Zika virus capsid encapsulating the viral genome. Cell Research, 28(4), 497.

Miller, A. S., Daley, J. M., Pham, N. T., Niu, H., Xue, X., Ira, G., & Sung, P. (2017). A novel role of the Dna2 translocase function in DNA break resection. Genes \& Development.

Daley, J. M., Jimenez-Sainz, J., Wang, W., Miller, A. S., Xue, X., Nguyen, K. A., … Sung, P. (2017). Enhancement of BLM-DNA2-mediated long-range DNA end resection by CtIP. Cell Reports, 21(2), 324--332.

Xue, X., Papusha, A., Choi, K., Bonner, J. N., Kumar, S., Niu, H., … others. (2016). Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. Genes \& Development.

Bonner, J. N., Choi, K., Xue, X., Torres, N. P., Szakal, B., Wei, L., … others. (2016). Smc5/6 mediated sumoylation of the Sgs1-Top3-Rmi1 complex promotes removal of recombination intermediates. Cell Reports, 16(2), 368--378.

Xue, X., Choi, K., Bonner, J. N., Szakal, B., Chen, Y.-H., Papusha, A., … others. (2015). Selective modulation of the functions of a conserved DNA motor by a histone fold complex. Genes \& Development.

Xue, X., Sung, P., & Zhao, X. (2015). Functions and regulation of the multitasking FANCM family of DNA motor proteins. Genes \& Development, 29(17), 1777--1788.

Xue, X., Choi, K., Bonner, J., Chiba, T., Kwon, Y., Xu, Y., … others. (2014). Restriction of replication fork regression activities by a conserved SMC complex. Molecular Cell, 56(3), 436--445.

Daley, J. M., Chiba, T., Xue, X., Niu, H., & Sung, P. (2014). Multifaceted role of the Topo III$\alpha$--RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection. Nucleic Acids Research, 42(17), 11083--11091.

Zhao, Q., Xue, X., Longerich, S., Sung, P., & Xiong, Y. (2014). Structural insights into 5′ flap DNA unwinding and incision by the human FAN1 dimer. Nature Communications, 5, 5726.

Xue, X., Raynard, S., Busygina, V., Singh, A. K., & Sung, P. (2013). Role of RPA in double Holliday Junction dissolution mediated by the BLM-Topo III $\alpha$-RMI1-RMI2 complex. Journal of Biological Chemistry, jbc--M113.

Daee, D. L., Ferrari, E., Longerich, S., Zheng, X., Xue, X., Branzei, D., … Myung, K. (2012). Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1. Journal of Biological Chemistry, 287(32), 26563--26575.

Tsai, S.-P., Su, G.-C., Lin, S.-W., Chung, C.-I., Xue, X., Dunlop, M. H., … Chi, P. (2012). Rad51 presynaptic filament stabilization function of the mouse Swi5--Sfr1 heterodimeric complex. Nucleic Acids Research, 40(14), 6558--6569.

Hohl, M., Kwon, Y., Galv\’an, Sandra Mu\~noz, Xue, X., Tous, C., Aguilera, Andr\’es, … Petrini, J. H. (2011). The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. Nature Structural \& Molecular Biology, 18(10), 1124.

Xue, X., Yu, H., Yang, H., Xue, F., Wu, Z., Shen, W., … others. (2008). Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. Journal of Virology, 82(5), 2515--2527.

Bartlam, M., Xue, X., & Rao, Z. (2008). The search for a structural basis for therapeutic intervention against the SARS coronavirus. Acta Crystallographica Section A: Foundations of Crystallography, 64(1), 204--213.

Xue, X., Yang, H., Shen, W., Zhao, Q., Li, J., Yang, K., … Rao, Z. (2007). Production of authentic SARS-CoV Mpro with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction. Journal of Molecular Biology, 366(3), 965--975.

Liang, W., Yang, H., Xue, X., Huang, Q., Bartlam, M., & Chen, S. (2006). Expression, crystallization and preliminary X-ray studies of the immunoglobulin-like domain 3 of human palladin. Acta Crystallographica Section F, 62(6), 556--558.

Yang, H., Xie, W., Xue, X., Yang, K., Ma, J., Liang, W., … others. (2005). Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biology, 3(10), e324.

Wu, D., Yang, H., Xue, X., Liang, W., Miao, X., Chen, S., & Pang, H. (2005). Oligomerization study of NHR3 and NHR4 domains from ETO protein involved in t(8;21)-associated acute myeloid leukemia. Chinese Science Bulletin, 50(9), 875–879. https://doi.org/https://doi.org/10.1007/BF02897381

Yang, H.-T., Wu, D.-H., Xue, X., Liang, W.-X., Miao, X.-Y., Pang, H., & Chen, S.-J. (2004). Cloning, expression, purification and crystallization of NHR3 domain from acute myelogenous leukemia-related protein AML1-ETO. Acta Biochimica et Biophysica Sinica, 36(8), 566--570.