Biography and expertise
Associate Professor, Chemistry and Biochemistry, Texas State University, San Marcos, TX (2024-present)
Assistant Professor, Chemistry and Biochemistry, Texas State University, San Marcos, TX (2018-2024)
Associate Research Scientist, Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT (2014-2018)
Postdoctoral Associate, Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT (2008-2014)
Ph.D., Biology, Tsinghua University, Beijing, China (2008)
B.S., Biochemistry, Nanjing University, Nanjing, China (2003)
Assistant Professor, Chemistry and Biochemistry, Texas State University, San Marcos, TX (2018-2024)
Associate Research Scientist, Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT (2014-2018)
Postdoctoral Associate, Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT (2008-2014)
Ph.D., Biology, Tsinghua University, Beijing, China (2008)
B.S., Biochemistry, Nanjing University, Nanjing, China (2003)
Education
Doctorate Degree
PhD in Biology
Tsinghua University, 2008
Bachelor's Degree
BS in Biochemistry
Nanjing University, 2003
Teaching Interests
Research Interests
Intellectual Property
Patents
- “Patent: Preparation and application of inhibitors targeting the main proteases of Coronaviruses.” Zihe Rao, Haitao Yang, Xiaoyu Xue, Kailin Yang, Mark Bartlam, Dawei Ma, Weiqing Xie. #200410087721.7.
Date awarded: 10/22/2004
Featured grants
- Xue, Xiaoyu (Principal). Mechanism of Smc5/6-mediated protein sumoylation in DNA repair, NIH (NIGMS), Federal, $592495. (Submitted: September 25, 2024, Funded: August 15, 2025 - June 30, 2029). Grant.
- Xue, Xiaoyu (Principal). Roles of the human UAP56 helicase in co-transcriptional R-loop resolution and genome maintenance, NIH/NIGMS, Federal, $436350. (Submitted: October 25, 2019, Funded: September 1, 2020 - August 31, 2024). Grant.
- Xue, Xiaoyu (Principal). Functions of the DNA/RNA motor protein AQR in R-loop resolution, NIH/NIEHS, Federal, $423725. (Funded: December 15, 2017 - November 30, 2020). Grant.
- Xue, Xiaoyu. Interplay between human BRCA1-BARD1 and DNA/RNA helicase ZGRF1 in R-loop resolution and genome maintenance, Research Enhancement Program (REP), Texas State University, $8000. (Submitted: October 6, 2023, Funded: January 1, 2024 - May 31, 2025). Grant.
- Xue, Xiaoyu. Functions of the Human ZGRF1 Helicase in DNA Damage Repair, Translational Health Research- Health Scholar Showcase 2021 Award, Texas State University, $5000. (Funded: May 5, 2021 - December 31, 2021). Grant.
Featured scholarly/creative works
- Xue, X., Fan, J., Li, S., Ignatyeva, S., Gallegos Elias, P. A., McEntire-Benitez, H. G., … Zhao, X. (2026). Multi-subunit collaboration enables Smc5/6 to function as a composite SUMO E3 complex. Nature Communications, 17(1). https://doi.org/10.1038/s41467-026-75592-7
- Bhandari, J., Guillén-Mendoza, C., Banks, K. P., Eliaz, L., Southwell, S., Eyaa, D., … Xue, X. (2024). The molecular chaperone ALYREF promotes R-loop resolution and maintains genome stability. The Journal of Biological Chemistry, 300(12), 107996. https://doi.org/10.1016/j.jbc.2024.107996
- Li, S., Mutchler, A., Zhu, X., So, S., Epps, J., Guan, D., … Xue, X. (2022). Multifaceted regulation of the sumoylation of the Sgs1 DNA helicase. The Journal of Biological Chemistry, 298(7), 102092. https://doi.org/10.1016/j.jbc.2022.102092
- Li, S., Bonner, J. N., Wan, B., So, S., Summers, A. S., Gonzalez, L., … Zhao, X. (2021). Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes & Development, 35(3–4), 261–272. https://doi.org/10.1101/gad.344739.120
- Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, S., Simonsen AKW, Viswalingam, K. S., … Lisby, M. (2020). The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells. Cell Reports, 32(1), 107849. https://doi.org/10.1016/j.celrep.2020.107849
Featured awards
- Award / Honor Recipient: College Achievement Award for Excellence in Scholarly/Creative Activities, College of Science and Engineering, Texas State University. 2024
- Award / Honor Recipient: College Achievement Award for Excellence in Scholarly/Creative Activities, College of Science and Engineering, Texas State University. 2022
- Award / Honor Recipient: Presidential Distinction Award for Excellence in Scholarly/Creative Activities, College of Science and Engineering, Texas State University. 2021
- Award / Honor Nominee: the International Young Scientist Awards. November 10, 2022
Featured service activities
- Other
Research Enhancement Program (REP)
- Other
IMBC committee
- Member
IMBC Graduate Admissions
- Member
Graduate Scholarship Committee
- Member
IMBC Graduate Admissions
- Member
Equipment Committee