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Dr. Xiaoyu Xue

  • Associate Professor - Chemistry and Biochemistry
Portrait of Dr. Xiaoyu Xue

Biography and education

Associate Professor, Chemistry and Biochemistry, Texas State University, San Marcos, TX (2024-present)
Assistant Professor, Chemistry and Biochemistry, Texas State University, San Marcos, TX (2018-2024)
Associate Research Scientist, Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT (2014-2018)
Postdoctoral Associate, Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT (2008-2014)
Ph.D., Biology, Tsinghua University, Beijing, China (2008)
B.S., Biochemistry, Nanjing University, Nanjing, China (2003)

Teaching Interests

Research Interests

  • Xue, Xiaoyu (Principal). Mechanism of Smc5/6-mediated protein sumoylation in DNA repair, NIH (NIGMS), Federal, $592495. (Submitted: September 25, 2024, Funded: August 15, 2025 - June 30, 2029). Grant.
  • Lewis, Karen A (Principal), Kerwin, Sean Michael (Co-Principal), Whitten, Steven T (Co-Principal), Kornienko, Alexander Vladimir (Supporting), Peterson, Ryan Loren (Supporting), Xue, Xiaoyu (Supporting). MRI: Acquisition of Automated Isothermal Titration Calorimeter for Biophysical Research at Texas State University, National Science Foundation, Federal, $262280. (Submitted: January 19, 2022, Funded: September 1, 2022 - August 31, 2025). Grant.
  • Xue, Xiaoyu (Principal). Roles of the human UAP56 helicase in co-transcriptional R-loop resolution and genome maintenance, NIH/NIGMS, Federal, $436350. (Submitted: October 25, 2019, Funded: September 1, 2020 - August 31, 2024). Grant.
  • Xue, Xiaoyu (Principal). Functions of the DNA/RNA motor protein AQR in R-loop resolution, NIH/NIEHS, Federal, $423725. (Funded: December 15, 2017 - November 30, 2020). Grant.
  • Xue, Xiaoyu. Interplay between human BRCA1-BARD1 and DNA/RNA helicase ZGRF1 in R-loop resolution and genome maintenance, Research Enhancement Program (REP), Texas State University, $8000. (Submitted: October 6, 2023, Funded: January 1, 2024 - May 31, 2025). Grant.
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  • Bhandari, J., Guillén-Mendoza, C., Banks, K. P., Eliaz, L., Southwell, S., Eyaa, D., … Xue, X. (2024). The molecular chaperone ALYREF promotes R-loop resolution and maintains genome stability. The Journal of Biological Chemistry, 300(12), 107996. https://doi.org/10.1016/j.jbc.2024.107996
  • Li, S., Mutchler, A., Zhu, X., So, S., Epps, J., Guan, D., … Xue, X. (2022). Multifaceted regulation of the sumoylation of the Sgs1 DNA helicase. The Journal of Biological Chemistry, 298(7), 102092. https://doi.org/10.1016/j.jbc.2022.102092
  • Li, S., Bonner, J. N., Wan, B., So, S., Summers, A. S., Gonzalez, L., … Zhao, X. (2021). Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes & Development, 35(3–4), 261–272. https://doi.org/10.1101/gad.344739.120
  • Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, S., Simonsen AKW, Viswalingam, K. S., … Lisby, M. (2020). The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells. Cell Reports, 32(1), 107849. https://doi.org/10.1016/j.celrep.2020.107849
  • Xue, X., Papusha, A., Choi, K., Bonner, J. N., Kumar, S., Niu, H., … others. (2016). Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. Genes \& Development.
View all scholarly/creative works
  • Award / Honor Recipient: College Achievement Award for Excellence in Scholarly/Creative Activities, College of Science and Engineering, Texas State University. 2024
  • Award / Honor Recipient: College Achievement Award for Excellence in Scholarly/Creative Activities, College of Science and Engineering, Texas State University. 2022
  • Award / Honor Recipient: Presidential Distinction Award for Excellence in Scholarly/Creative Activities, College of Science and Engineering, Texas State University. 2021
  • Award / Honor Nominee: the International Young Scientist Awards. November 10, 2022
  1. Other

    IMBC committee

  2. Member

    IMBC Graduate Admissions

  3. Member

    IMBC Faculty Search Committee

  4. Member

    Faculty Evaluation Committee

  5. Other

    Research Enhancement Program (REP)

  6. Member

    Graduate Scholarship Committee

  7. View all activities