Faculty Profiles

Bretin, L., Husiev, Y., Ramu, V., Zhang, L., Hakkennes, M., Abyar, S., … Bonnet, S. (2024). Red-Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage. Angewandte Chemie International Edition English, e202316425.

Aksenov, D., Smith, J., Aksenov, A., Prityko, L., Aksenov, N., Kuzminov, I., … Kornienko, A. V. (2024). 2-(3-Indolyl)acetamides and their oxazoline analogues: Anticancer SAR study. Bioorganic and Medicinal Chemistry Letters, 102, 129681.

van der Westhuyzen, A., Ashraf, N., Conradie, D., Loots, L., Kaschula, C., Pelly, S., … van Otterlo, W. (2024). Improved rigidin-inspired antiproliferative agents with modifications on the 7-deazahypoxanthine C7/C8 ring systems. Journal of Medicinal Chemistry, 67, 9950–9975.

Maslivetc, V., Hasan, N., Boari, A., Zejnelovski, A., Evidente, A., Sun, D., & Kornienko, A. V. (2024). Ophiobolin A derivatives with enhanced activities under tumor-relevant acidic conditions. Bioorganic and Medicinal Chemistry Letters, 110, 129863.

Ingels, A., Scott, R., Hooper, A., van der Westhuyzen, A., Wagh, S., de Meester, J., … Mathieu, V. (2024). New hemisynthetic derivatives of sphaeropsidin phytotoxins triggering severe endoplasmic reticulum swelling in cancer cells. Scientific Reports, 14, 14674.

Arutiunov, N., Aksenov, D., Edvall, C., Kurenkov, I., Aksenova, I., Zatsepilina, A., … Kornienko, A. V. (2024). Syntheses of 3-(2-nitrovinyl)indoles, benzo[a]carbazoles, naphto[2,1-a]carbazoles, and 1-hydroxy-b-carbolines lead to identification of antiproliferative compounds active under hypoxia. Journal of Organic Chemistry, 89, 13923–13936.

Wagh, S. B., Berthold, D., Majeed, I., Lewis, L., Schilter, D., Mertens, B., … Kornienko, A. V. (2024). Sphaeropsidin A C15-C16 Cross-Metathesis Analogues with Potent Anticancer Activity. ChemMedChem, e202400288. https://doi.org/10.1002/cmdc.202400288

van der Westhuyzen, A. E., Ashraf, N., Conradie, D., Loots, L., Kaschula, C. H., Pelly, S. C., … van Otterlo, W. A. (2024). Improved Rigidin-Inspired Antiproliferative Agents with Modifications on the 7-Deazahypoxanthine C7/C8 Ring Systems. Journal of Medicinal Chemistry, 67(12), 9950–9975. https://doi.org/10.1021/acs.jmedchem.3c02473

Aksenov, D. A., Smith, J. L., Aksenov, A. V., Prityko, L. A., Aksenov, N. A., Kuzminov, I. K., … Kornienko, A. V. (2024). 2-(3-Indolyl)acetamides and their oxazoline analogues: Anticancer SAR study. Bioorg Med Chem Lett., 102, 1–6. https://doi.org/10.1016/j.bmcl.2024.129681

Aksenov, N., Arutiunov, N., Aksenov, A., Kirilov, N., Aksenova, I., Aksenov, D., … Kornienko, A. V. (2023). Synthesis of β-Carbolines with Electrocyclic Cyclization of 3-Nitrovinylindoles. International Journal of Molecular Sciences, 24, 13107.

Arutiunov, N., Aksenov, A., Aksenov, D., Kurenkov, I., Aksenova, I., Zatsepilina, A., … Kornienko, A. V. (2023). Convenient synthesis of (Z)-3-(1-aryl-2-nitrovinyl)-indoles. Tetrahedron Letters, 129, 154722.

Ranganathan, S., Kornienko, A. V., Evidente, A., Romo, D., & Taube, J. (2023). Triple negative breast cancer targeted by Ophiobolin A: Epithelial-mesenchymal transition take the lead. In Cancer Research (Vol. 83).

Bretin, L., Vadde, R., Zheng, S., Gerhard, S., Zander, S., Kornienko, A. V., & Bonnet, S. (2023). Testing ruthenium-based photoactivated chemotherapy on tumor-bearing mice models as a new treatment for uveal melanoma. In Photodiagnosis and Photodynamic Therapy (March, Vol. 41, p. 103403). ScienceDirect.

Bretin, L., Husiev, Y., Ramu, V., Zhang, L., Hakkennes, M., Abyar, S., … Bonnet, S. (2023). Red-Light Activation of Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage. Angewandte Chemie, 63(5), e202316425. https://doi.org/10.1002/anie.202316425

C., A. J., Oviedo, A., Zhao, Z., Du, L., & Kornienko, A. V. (2023). Discovery of 5-sulfonyltetrazoles as neuroblastoma differentiation agents. Bioorg. Med. Chem. Lett., 94, 1–4. Retrieved from https://doi.org/10.1016/j.bmcl.2023.129455

Mathieu, V., Superchi, S., Masi, M., Scafato, P., KORNIENKO, A. V., & Evidente, A. (2022). In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus Australiensis Radicinin. Toxins, 14(517), 1–10.

Maslivetc, V., La Clair, J. J., & Kornienko, A. V. (2022). Three-component assembly of stabilized fluorescent isoindoles. RSC Advances, 12.

Mathieu, V., Laguera, B., Masi, M., Dulanto, S. A., Bingham, T., Hernandez, L., … Lane, M. A. (2022). Amaryllidaceae Alkaloids Decrease the Proliferation, Invasion, and Secretion of Clinically Relevant Cytokines by Cultured Human Colon Cancer Cells. Biomolecules, 12.

Venkatesan, R., Hussein, M. A., Moses, L., Liu, J., Khetani, S., Kornienko, A. V., & Munirathinam, G. (2022). Polygodial, a Sesquiterpene Dialdehyde, Activates Apoptotic Signaling in Castration‐Resistant Prostate Cancer Cell Lines by Inducing Oxidative Stress. Cancers, 14.

Wagh, S., Maslivetc, V., La Clair, J. J., & Kornienko, A. V. (2022). Medicinal chemical optimization of fluorescent pyrrole-based COX-2 probes. Tetrahedron, 123.

Aksenov, A., Kirilov, N., Arutuinov, N., Aksenov, D., Kuzminov, I., Aksenov, N., … Rubin, M. (2022). Reductive Cleavage of 4′H‐Spiro[indole-3,5′-isoxazoles] En Route to 2‐(1H‐Indol-3-yl)acetamides with Anticancer Activities. The Journal of Organic Chemistry, 87, 13955–13964.

Stollmaier, J. G., Thomson, J., Endoma-Arias, M. A., Simionescu, R., Vernaza, A., Mesa-Diaz, N., … Hudlicky, T. (2022). Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity. Molecules, 27, 1–17. https://doi.org/10.3390/molecules27134141

Habaz, L., Bedard, K., Smith, M., Du, L., Kornienko, A., & Hudlicky, T. (2022). Conversion of Natural Narciclasine to Its C-1 and C-6 Derivatives and Their Antitumor Activity Evaluation: Some Unusual Chemistry of Narciclasine. Molecules, 27, 1–13. https://doi.org/10.3390/molecules27123809

Reisenauer, K. N., Tao, Y. F., Das, P., Song, S. X., Svatek, H., D, P. S., … Taube, J. (2021). Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived  sester-terpenoid ophiobolin A. Scientific Reports, 11(10652).

Wagh, S. B., Maslivetc, V., La Clair, J. J., & Kornienko, A. V. (2021). Lessons in organic fluorescent probe discovery. ChemBioChem, 22, 1–32.

Aksenov, A. V., Arutiunov, N. A., Kirilov, N. K., Aksenov, D. A., Grishin, I. Y., Aksenov, N. A., … Rubin, M. (2021). [3+2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor. Organic & Biomolecular Chemistry, 19, 7234. https://doi.org/doi: 10.1039/d1ob01141c

Maslivetc, V., Laguera, B., Chandra, S., Dasari, R., Olivier, W., Smith, J., … Kornienko, A. V. (2021). Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets. International Journal of Molecular Sciences, 22.

Ticli, V., Zhao, Z., Du, L., Kornienko, A. V., & Hudlicky, T. (2021). Synthesis and biological evaluation of 10-benzyloxy-Narciclasine. Tetrahedron, 101, 132505. https://doi.org/doi: 10.1016/j.tet.2021.132505

Turner, D., Edwards, L., Kornienko, A. V., Frolova, L., & Rogelj, S. (2020). Synergistic action of substituted indole derivatives and clinically used antibiotics against drug-resistant bacteria. Future Microbiology, ahead of print.

van der Westhuyzen, A., Ingels, A., Rosière, R., Amighi, K., Oberer, L., Gustafson, K., … van Otterlo, W. (2020). Deciphering the chemical instability of sphaeropsidin A under physiological conditions – degradation studies and structural elucidation of the major metabolite. Organic & Biomolecular Chemistry, 18, 8147–8160.

Wagh, S., Maslivetc, V., La Clair, J., & Kornienko, A. V. (2020). A fluorescent target-guided Paal–Knorr reaction. RSC Advances, 10, 37035–37039.

Aksenov, N. A., Aksenov, A. V., Kirilov, N. K., Arutiunov, N. A., Aksenov, D. A., Maslivetc, V., … Kornienko, A. V. (2020). Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity. Organic & Biomolecular Chemistry, 18(34), 6651–6664. https://doi.org/https://doi.org/10.1039/D0OB01007C

Eyong, K. O., Ketsemen, H. L., Zhao, Z., Du, L., Ingels, A., Mathieu, V., … Romo, D. (2020). Anti-proliferative activity of naphthoquinones and indane carboxylic acids from lapachol against a panel of human cancer cell lines. Medicinal Chemistry Research, 29, 1058–1066. https://doi.org/10.1007/s00044-020-02545-0

Kornienko, A. V., Masi, M., Dasari, R., Evidente, A., & Mathieu, V. (2019). Chemistry and biology of ophiobolin A and its congeners. Bioorganic and Medicinal Chemistry Letters, 29, 859–869.

Kornienko, A. V., Turner, D., Just, J., Dasari, R., Smith, J., Bissimber, A., & Rogelj, S. (2019). Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes. NATURAL PRODUCT RESEARCH, DOI: 10.1080/14786419.2019.1597350.

Kornienko, A. V., Lefranc, F., Koutsaviti, A., Ioannou, E., Roussis, V., Kiss, R., & Newman, D. (2019). Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity. Natural Product Reports, 36, 810–841.

Kornienko, A. V., Pereira, R., Evdokimov, N., Lefranc, F., Valentao, P., Pereira, D., … Gomes, N. (2019). Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets. Marine Drugs, 17, 329.

Kornienko, A. V., Karakoyun, C., Masi, M., Chimino, A., Ali Onur, M., Unver Somer, N., & Evidente, A. (2019). A Brief Up-to-Date Overview of Amaryllidaceae Alkaloids: Phytochemical Studies of Narcissus tazetta subsp. tazetta L., Collected in Turkey. Natura Product Communications, 1–6.

Kornienko, A. V., Masi, M., Van slambrouck, S., Gunawardana, S., van Rensburg, M., James, P., … Evidente, A. (2019). Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: Anticancer activity of coccinine and montanine. South African Journal of Botany, 126, 277–281.

Kornienko, A. V., Segat, G., Moreira, C., Santos, E., Heller, M., Schwanke, R., … Calixto, J. (2019). A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma. Investigational New Drugs, https://doi.org/10.1007/s10637-019-00849-6.

Van Rixel, V. H. S., Ramu, V., Auyeung, A. B., Beztsinna, N., Leger, D. Y., Lameijer, L. N., … Bonnet, S. (2019). Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model. Journal of the American Chemical Society, 141(46), 18444–18454. https://doi.org/10.1021/jacs.9b07225

Aksenov, A. V., Aksenov, D. A., Arutiunov, N. A., Aksenov, N. A., Aleksandrova, E. V., Zhao, Z., … Rubin, M. (2019). Synthesis of Spiro[indole-3,5’-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles. The Journal of Organic Chemistry, 84(11), 7123–7137. https://doi.org/10.1021/acs.joc.9b00808

KORNIENKO, A., De La Chapa, J., Singha, P., Sallaway, M., Self, K., Nasreldin, R., … Gonzales, C. (2018). Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma. International Journal of Oncology, 53, 2627–2636.

KORNIENKO, A., Edwards, L., Turner, D., Champion, C., Khandelwal, M., Zingler, K., … Rogelj, S. (2018). Photoactivated 2,3-distyrilindoles kill multi-drug resistant bacteria. Bioorganic & Medicinal Chemistry Letters, 28, 1879–1886.

KORNIENKO, A., Garcia, D., Goncalves-de-Albuquerque, C., da Silva, C., Kiss, R., Dasari, R., … Burth, P. (2018). Effect of polygodial and its direct derivatives on the mammalian Na+/K+-ATPase activity. European Journal of Pharmacology, 831, 1–8.

KORNIENKO, A., Dasari, S., Samy, A., Narvekar, P., Dontaraju, V., Dasari, R., & Munirathinam, G. (2018). Polygodial analog induces apoptosis in LNCaP prostate cancer cells. European Journal of Pharmacology, 828, 154–162.

KORNIENKO, A., Govindaraju, K., Ingels, A., Hasan, M., Sun, D., Mathieu, V., … Evidente, A. (2018). Synthetic analogues of the montanine-type alkaloids with activity against apoptosis-resistant cancer cells. Bioorganic & Medicinal Chemistry Letters, 28, 589–593.

KORNIENKO, A., Pellegrino, S., Meyer, M., Zorbas, C., Bouchta, S., Saraf, K., … Yusupov, M. (2018). The Amaryllidaceae alkaloid haemanthamine binds the eukaryotic ribosome to repress cancer cell growh. Structure, 26, 416–425.

Dasari, R., Blauz, A., Medellin, D. C., Kassim, R. M., Viera, C., Santarosa, M., … Kornienko, A. V. (2018). Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins. Chem Med Chem, 14, 322–333. https://doi.org/10.1002/cmdc.201800658

KORNIENKO, A., Aksenov, A., Aksenov, N., De Carvalho, A., Mathieu, V., Aksenov, D., … Griaznov, G. (2018). A nitroalkane-based approach to one-pot three-component synthesis of isocyptolepine and its analogs with potent anti-cancer activities. RSC Advances, 8, 36980.

KORNIENKO, A., van der Westhuyzen, A., Frolova, L., & van Otterlo, W. (2018). The rigidins: isolation, bioactivity, and total synthesis – novel pyrrolo[2,3-d]pyrimidine analogues using multicomponent reactions. In In “The alkaloids” (Vol. 79, pp. 191–220). SAN MARCOS, US: Elsevier Inc. Academic Press.

Govindaraju, K., Masi, M., Colin, M., Mathieu, V., Evidente, A., Hudnall, T. W., & Kornienko, A. V. (2018). Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine. Molecules, 23, 255–263. https://doi.org/doi:10.3390/molecules23020255

Carvalho, A., Chu, J., Mainguet, C., Kiss, R., Vandenbussche, G., Massereel, B., … Mathieu, V. (2017). A harmine-derived beta-carboline displays anticancer effects in vitro by targeting protein synthesis. Eur. J. Pharmacol., 805, 25.

Aksenov, A., Aksenov, D., Orazova, N., Aksenov, N., Griaznov, G., de Carvalho, A., … Rubin, M. (2017). One-pot, three-component assembly of indoloquinolines: Total synthesis of isocryptolepine. J. Org. Chem., 82, 3011.

Dasari, R., La Clair, J. J., & Kornienko, A. (2017). Irreversible protein labeling by Paal-Knorr conjugation. ChemBioChem, 18, 1792.

Kornienko, A., & La Clair, J. J. (2017). Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Nat. Prod. Rep., 34, 1051.

Li, Y., Scott, R., Bartholomeusz, G. A., Kornienko, A., Bills, G. F., & Hooper, A. (2017). Aspergillus candidis is a newly recognized source of sphaeropsidin A: Isolation, semisynthetic derivatization and anticancer evaluation. Bioorg. Med. Chem. Lett., 27, 5436.

Pereira, R., Dasari, R., Lefranc, F., Kornienko, A., Kiss, R., & Gomes, N. (2017). Targeting enzymatic pathways with marine-derived clinical agents. In Natural products targeting clinically relevant enzymes. Wiley-VCH Verlag GnmH & Co.

Ciavatta, M., Lefranc, F., Carbone, M., Mollo, E., Gavagnin, M., Betancourt, T., … Kiss, R. (2017). Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance. Medicinal Research Reviews, 37(4), 702.

Ciavatta, M. L., Lefranc, F., Carbone, M., Mollo, E., Gavagnin, M., Betancourt, T., … Kiss, R. (2017). Anticancer Compounds from Marine Mollusks. Medicinal Research Reviews, 37, 702–801. https://doi.org/DOI 10.1002/med.21423

Medellin, D. C., Zhou, Q., Scott, R., Hill, R. M., Frail, S. K., Dasari, R., … Kornienko, A. V. (2016). Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities. J. Med. Chem., 59, 480.

Cimmino, A., Mathieu, V., Masi, M., Baroncelli, R., Boari, A., Pescitelli, G., … Evidente, A. (2016). Higginsianins A and B, Two Diterpenoid alpha-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity. J. Nat. Prod., 79, 116.

Evdokimov, N. V., Magedov, I. V., McBrayer, D., & Kornienko, A. (2016). Isatin derivatives with activity against apoptosis-resistant cancer cells. Bioorg. Med. Chem. Lett., 26, 1558.

Panayides, J. L., Mathieu, V., Banuls, L. M. Y., Apostolellis, H., Dahan-Farkas, N., Davids, H., … van Otterlo, W. A. L. (2016). Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides. Bioorg. Med. Chem. Lett., 14, 2617.

Henry, S., Kidner, R., Reisenauer, M. R., Magedov, I. V., Quintana, R., Kiss, R., … Frolova, L. V. (2016). 5,10b-Ethanophenanthridine Amaryllidaceae Alkaloids Inspire the Discovery of Novel Bicyclic Ring Systems with Activity against Drug Resistant Cancer Cells. Eur. J. Med. Chem., 313.

Gomes, N. G., Dasari, R., Chandra, S., Kiss, R., & Kornienko, A. (2016). Marine invertebrate metabolites with anticancer acitivities: solutions to the “supply problem". Mar. Drugs, 14, 98.

Beuzer, P., Axelrod, J., Trzoss, L., Fenical, W., Dasari, R., Evidente, A., … La Clair, J. J. (2016). Single dish gradient screening of small molecule localization. Org. Biomol. Chem., 14, 8241.

Masi, M., Cimmino, A., Maddau, L., Kornienko, A., Tuzi, A., & Evidente, A. (2016). Crystal structure and absolute configuration of sphaeropsidin A and its 6-O-p-bromobenzoate. Tetrahedron Lett., 57.

Dasari, R., De Carvalho, A., Medellin, D. C., Middleton, K. N., Hague, F., Volmar, M. N. M., … Kornienko, A. V. (2015). Wittig Derivatization of Sesquiterpenoid Polygodial Leads to Cytostatic Agents with Activity Against Drug Resistant Cancer Cells and Capable of Pyrrolylation of Primary Amines. Eur. J. Med. Chem, 103, 226–237.

Dasari, R., De Carvalho, A., Medellin, D. C., Middleton, K. N., Hague, F., Volmar, M. N. M., … Kornienko, A. V. (2015). Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial Against Drug Resistant Cancer Cells. ChemMedChem, 10, 2014–2026.

Dasari, R., Masi, M., Lisy, R., Ferderin, M., English, L. R., Cimino, A., … Kornienko, A. V. (2015). Fungal Metabolite Ophiobolin A as a Promising Anti-Glioma Agent: In Vivo Evaluation, Structure-Activity Relationship and Unique Pyrrolylation of Primary Amines. Bioorg. Med. Chem. Lett, 25, 4544.

Evidente, A., Kornienko, A. V., Lefranc, F., Cimino, A., Dasari, R., Evidente, M., … Kiss, R. (2015). Sesterterpenoids with anticancer activity. Curr. Med. Chem., 22.

Chantome, A., Lefranc, F., Cimino, A., Miklos, W., Paulitschke, V., Mohr, T., … Kiss, R. (2015). Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase. Cell. Mol. Life Sci, 72, 3731–3746.

Mikhalin, A. A., Evdokimov, N. M., Frolova, L. V., Magedov, I. V., Kornienko, A. V., Johnston, R., … Tartis, M. S. (2015). Lipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification. J. Liposome Res, 25, 232–260.

Aksenov, A. V., Smirnov, A. N., Magedov, I. V., Reisenaur, M. R., Aksenov, N. A., Aksenova, I. V., … Frolova, L. V. (2015). Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates Against Drug-Resistant Cancer Cells. J. Med. Chem, 58, 2206–2220.

Kornienko, A. V., Evidente, A., Vurro, M., Mathieu, V., Cimmino, A., van Otterlo, W. A. L., … Kiss, R. (2015). Towards a Cancer Drug of Fungal Origin. J. Liposome Res, 35, 937–967.

Masi, M., Frolova, L. V., Yu, X., Mathieu, V., Cimmino, A., De Carvalho, A., … Evidente, A. (2015). Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer. Fitoterapia, 102, 41–48.

Scott, R., Karkari, M., Reisenaur, M. R., Rodrigues, R., Dasari, R., Smith, W. R., … Kornienko, A. V. (2014). Synthetic and Biological Studies of Tubulin Targeting C2-Substituted 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins. ChemMedChem, 9, 1428.

Dasari, R., Banuls, L. M. Y., Masi, M., Pelly, S. C., Mathieu, V., Green, I. R., … Kornienko, A. V. (2014). C1,C2-Ether Derivatives of the Amaryllidaceae Alkaloid Lycorine: Retention of Activity of Highly Lipophilic Analogues Against Apoptosis-Resistant Cancer Cells. Bioorg. Med. Chem. Lett, 24, 923.

Rastogi, S. K., Medellin, D. C., & Kornienko, A. V. (2014). C-H Functionalization Directed by Transformable Nitrogen Heterocycles: Synthesis of ortho-Oxygenated Arylnaphthalenes from Arylphthalazines. Org. Biomol. Chem, 12, 410.

Botes, M. G., Pelly, S. C., Blackie, M. A. L., Kornienko, A. V., & van Otterlo, W. A. L. (2014). Synthesis of 4-azapodophyllotoxins with anticancer activity by multicomponent reactions. Chem. Heterocycl. Comp, 139.

Evidente, A., Kornienko, A. V., Cimmino, A., Andolfi, A., Lefranc, F., Mathieu, V., & Kiss, R. (2014). Fungal metabolites with anticancer activity. Nat. Prod. Rep, 31, 617.

Dasari, R., & Kornienko, A. V. (2014). First Multicomponent Synthesis of Pyrrolo[2,3-d]pyrimidines. Chem. Heterocycl. Comp, 160.

Frolova, L. V., Magedov, I. V., Romero, A. E., Karki, M., Otero, I., Hayden, K., … Kornienko, A. V. (2013). Exploring Natural Product Chemistry and Biology with Multicomponent Reactions. 5. Discovery of a Novel Tubulin-Targeting Scaffold Derived from the Rigidin Family of Marine Alkaloids. J. Med. Chem, 56, 6886.

Aksenov, A. V., Smirnov, A. N., Aksenov, N. A., Aksenova, I. V., Frolova, L. V., Kornienko, A. V., … Rubin, M. (2013). Metal-FreeTransannulation Reaction of Indoles with Nitrostyrenes: A Simple Practical Synthesis of 3-Substituted 2-Quinolones. Chem. Commun, 49, 9305.

Masi, M., Andolfi, A., Mathieu, V., Boari, A., Cimmino, A., Banuls, L. M. Y., … Evidente, A. (2013). Fischerindoline, a Pyrroloindole Terpenoid Isolated from  Neosartorya pseudofischeri, with In Vitro Growth Inhibitory Activity in Human Cancer Cell Lines. Tetrahedron, 69, 7466.

Kornienko, A. V., Mathieu, V., Rastogi, S., Lefranc, F., & Kiss, R. (2013). Perspective: Therapeutic Agents Triggering Non-Apoptotic Cancer Cell Death. J. Med. Chem, 56, 4823.

Magedov, I. V., Lefranc, F., Frolova, L. V., Banuls, L. M. Y., Peretti, A. S., Rogelj, S., … Kornienko, A. V. (2013). Antiproliferative Activity of 2,3-Disubstituted Indoles Toward Apoptosis-Resistant Cancers Cells. Bioorg. Med. Chem. Lett, 23, 3277.

Bury, M., Girault, A., Megalizzi, V., Spiegl-Kreinecker, S., Mathieu, V., Berger, W., … Kiss, R. (2013). Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity. Cell Death Dis, 4.

Van Goietsenoven, G., Mathieu, V., Lefranc, F., Spiegl-Kreinecker, S., Kornienko, A. V., Evidente, A., & Kiss, R. (2013). Narciclasine as well as other Amaryllidaceae Isocarbostyrils are Promising GTPase-Targeting Agents against Brain Cancers. Med. Res. Rev, 33.

Jucov, E., Kornienko, A. V., Masi, M., Evidente, A., & Antipin, M. (2013). Narciclasine. Acta Cryst. E., 9–10.

Magedov, I. V., Evdokimov, N. M., Karki, M., Peretti, A. S., Lima, D. T., Frolova, L., … Kornienko, A. V. (2012). Reengineered Epipodophyllotoxin. Chem. Commun, 48(10416).

Vshyvenko, S., Scattolon, J., Hudlicky, T., Romero, A. E., Kornienko, A. V., Ma, D., … Pandey, S. (2012). Unnatural C-1 homologues of pancratistatin: Synthesis and promising biological activities. Can. J. Chem, 90(932).

Magedov, I. V., Kireev, A. S., Jenkins, A. R., Evdokimov, N. M., Lima, D. T., Tongwa, P., … Kornienko, A. V. (2012). Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with Anticancer Activity. Bioorg. Med. Chem. Lett, 22(5195).

Luchetti, G., Johnston, R., Mathieu, V., Lefranc, F., Hayden, K., Andolfi, A., … Kornienko, A. V. (2012). Bulbispermine: A Crinine-Type Amaryllidaceae Alkaloid Exhibiting Cytostatic Activity towards Apoptosis-Resistant Glioma Cells. ChemMedChem, 7(518).

Cimmino, A., Evidente, A., Mathieu, V., Andolfi, A., Lefranc, F., Kornienko, A. V., & Kiss, R. (2012). Phenazines and Cancer. Nat. Prod. Rep, 29(487).

Abid, O. R., Khalid, M., Hussain, M. T., Hanif, M., Quadeer, G., Rama, N. H., … Khan, K. M. J. (2012). Synthesis and Anticancer, Antimetastatic Evaluation of Some New Fluorinated Isocoumarins and 3,4-Dihydroisocoumarins. J. Fluor. Chem, 135(240).

Magedov, I. V., & Kornienko, A. V. (2012). Multicomponent Reactions in Alkaloid-Based Drug Discovery. Chem. Heterocycl. Comp, 38.

Evdokimov, N., Lamoral-Theys, D., Mathieu, V., Andolfi, A., Pelly, S., van Otterlo, W., … Kornienko, A. V. (2011). In Search of a Cytostatic Agent Derived from the Alkaloid Lycorine: Synthesis and Growth Inhibitory Properties of Lycorine Derivatives. Bioorg. Med.  Chem, 19(7252).

Frolova, L. V., Malik, I., Uglinskii, P. Y., Rogelj, S., Kornienko, A. V., & Magedov, I. V. (2011). Multicomponent synthesis of 2,3-dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: a novel heterocyclic scaffold with antibacterial activity. Tetrahedron Lett, 52(6643).

Vshyvenko, S., Scattolon, J., Hudlicky, T., Romero, A. E., & Kornienko, A. V. (2011). Synthesis of C-1 Homologues of Pancratistatin and their Preliminary Biological Evaluation. Bioorg. Med. Chem. Lett, 21(4750).

Evdokimov, N. M., Kornienko, A. V., & Magedov, I. V. (2011). Aryliodine (III) Diacetates as Substrates for Pd-Ag Catalyzed Arylation of Alkenes. Tetrahedron Lett, 52(4327).

Seth, D., Hayden, K., Malik, I., Porch, N., Tang, H., Rogelj, S., … Magedov, I. V. (2011). Unprecedented C-2 Arylation of Indole with Diazonium Salts: Syntheses of 2,3-Disubstituted Indoles and their Antimicrobial Activity. Bioorg. Med.  Chem, 21(4720).

Magedov, I. V., Frolova, L., Manpadi, M., Bhoga, U. D., Tang, H., Evdokimov, N. M., … Kornienko, A. V. (2011). Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis. J. Med. Chem, 54(4234).

Evdokimov, N. M., van Slambrouck, S., Heffeter, P., Tu, L., Le Calve, B., Lamoral-Theys, D., … Magedov, I. V. (2011). Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 3. Fused Uracil-Containing Heterocycles as Novel Topoisomerase-Targeting Agents. J. Med. Chem, 54.

Frolova, L. V., Evdokimov, N. M., Hayden, K., Malik, I., Rogelj, S., Kornienko, A. V., & Magedov, I. V. (2011). One-Pot Multicomponent Synthesis of Diversely Substituted 2-Aminopyrroles. A short General Synthesis of Rigidins A, B, C, and D. Org. Lett, 13(1118).

Van Goietsenoven, G., Hutton, J., Becker, J. P., Lallemand, B., Robert, F., Lefranc, F., … Mathieu, V. (2010). Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. FASEB J, 24(4575).

Van Goietsenoven, G., Andolfi, A., Lallemand, B., Cimmino, A., Lamoral-Theys, D., Gras, T., … Kiss, R. (2010). Amaryllidaceae Alkaloids Belonging to Different Structural Subgroups Display Activity against Apoptosis-Resistant Cancer Cells. J. Nat. Prod, 73(1223).

Lamoral-Theys, D., Pottier, L., Kerff, F., Dufranse, F., Proutiere, F., Wauthoz, N., … Dubois, J. (2010). Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli. Bioorg. Med. Chem, 18(3823).

Collins, J., Rinner, U., Moser, M., Hudlicky, T., Ghiviriga, I., Romero, A. E., … Pandey, S. (2010). Chemoenzymatic Synthesis of Amaryllidaceae Constituents and Biological Evaluation of their C-1 Analogues. The Next Generation Synthesis of 7-Deoxypancratistatin and trans-Dihydrolycoricidine. J. Org. Chem, 75(3069).

Lamoral-Theys, D., Decastecker, C., Mathieu, V., Dubois, J., Kornienko, A. V., Kiss, R., … Pottier, L. (2010). Lycorine and its Derivatives for Anticancer Drug Design. Mini-Rev. Med. Chem, 10(41).

Lamoral-Theys, D., Pottier, L., Dufrasne, F., Neve, J., Dubois, J., Kornienko, A. V., … Ingrassia, L. (2010). Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity. Curr. Med. Chem, 17(812).

Lamoral-Theys, D., Andolfi, A., Van Goietsenoven, G., Cimmino, A., Le Calve, B., Wauthoz, N., … Evidente, A. (2009). Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Anti-Tumor Activity in Cancer Cells that Display Resistance to Proapoptotic Stimuli: an Investigation of Structure-Activity Relationship and Mechanistic Insight. J. Med. Chem, 52(6244).

Manpadi, M., Kireev, A. S., Magedov, I. V., Altig, J., Tongwa, P., Antipin, M. Y., … Kornienko, A. V. (2009). Synthesis of Structurally Simplified Analogues of Pancratistatin: Truncation of the Cyclitol Ring. J. Org. Chem, 74(7122).

Evidente, A., & Kornienko, A. V. (2009). Anticancer Evaluation of Structurally Diverse Amaryllidaceae Alkaloids and their Synthetic Derivatives. Phytochem. Rev, 8(449).

Evidente, A., Kireev, A. S., Jenkins, A. R., Romero, A. E., Steelant, W. F. A., van Slambrouck, S., & Kornienko, A. V. (2009). Biological Evaluation of Structurally Diverse Amaryllidaceae Alkaloids and their Synthetic Derivatives: Discovery of Novel Leads for Anticancer Drug Design. Planta Med, 75(501).

Luchetti, G., Ding, K., d’Alarcao, M., & Kornienko, A. V. (2008). Enantio- and Diastereodivergent Synthetic Route to Multifarious Cyclitols from D-Xylose via Ring-Closing Metathesis. Synthesis, (3142).

Luchetti, G., Ding, K., Kornienko, A. V., & d’Alarcao, M. (2008). Synthesis of Differentially Protected myo- and chiro-Inositols from D-Xylose; Stereoselectivity in Intramolecular SmI2-Promoted Pinacol Reactions. Synthesis, (3148).

Kornienko, A. V., & Evidente, A. (2008). Chemistry, Biology and Medicinal Potential of Narciclasine and its Congeners. Chem. Rev, 108(1982).

Magedov, I. V., Luchetti, G., Evdokimov, N. M., Manpadi, M., Steelant, W. F. A., van Slambrouck, S., … Kornienko, A. V. (2008). Novel Three-Component Synthesis and Antiproliferative Properties of Diversely Functionalized Pyrrolines. Bioorg. Med. Chem. Lett, 18(1392).

Sigstedt, S. C., Hooten, C. J., Callewaert, M. C., Jenkins, A. R., Romero, A. E., Pullin, M. J., … Steelant, W. F. A. (2008). Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. Int. J. Oncol, 32(1085).

Magedov, I. V., Manpadi, M., Ogasawara, M. A., Dhawan, A. S., Rogelj, S., Van Slambrouck, S., … Kornienko, A. V. (2008). Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 2. Antiproliferative and Antitubulin Activities of Pyrano[3,2-c]pyridones and Pyrano[3,2-c]quinolones. J. Med. Chem, 51(2561).

Manpadi, M., & Kornienko, A. V. (2008). Total Syntheses of Pancratistatin. Org. Prep. Proced. Int, 40(107).

Magedov, I. V., Manpandi, M., Rozhkova, E., Przheval’skii, N. M., Rogelj, S., Shors, S. T., … Kornienko, A. V. (2007). Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis: Dihydropyridopyrazole Analogues of Podophyllotoxin. Bioorg. Med. Chem. Lett, 17(1381).

van Slambrouck, S., Daniels, A. L., Hooten, C. J., Brock, S. L., Jenkins, A. R., Ogasawara, M. A., … Steelant, W. F. A. (2007). Effects of crude aqueous Medicinal Plant Extracts on growth and invasion of breast cancer cells. Oncology Reports, 17(1487).

Magedov, I. V., Manpadi, M., Evdokimov, N. M., Elias, E. M., Rozhkova, E., Ogasawara, M. A., … Kornienko, A. V. (2007). Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis. Bioorg. Med. Chem. Lett, 17(3872).

Evdokimov, N. M., Kireev, A. S., Yakovenko, A. A., Antipin, M. Y., Magedov, I. V., & Kornienko, A. V. (2007). One-Step Synthesis of Heterocyclic Privileged Medicinal Scaffolds Using a Multicomponent Reaction of Malononitrile with Aldehydes and Thiols. J. Org. Chem, 72(3443).

Magedov, I. V., Manpadi, M., van Slambrouck, S., Steelant, W. F. A., Rozhkova, E., Przeval’skii, N. M., … Kornienko, A. V. (2007). Discovery and Investigation of Antiproliferative and Apoptosis-Inducing Properties of New Heterocyclic Podophyllotoxin Analogues Accessible by a One-Step Multicomponent Synthesis. J. Med. Chem, 50(5183).

Manpadi, M., Uglinskii, P. Y., Rastogi, S. K., Cotter, K. M., Wong, Y. S. C., Anderson, L. A., … Kornienko, A. V. (2007). Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties. Org. Biomol. Chem, 5(3865).

Evdokimov, N. M., Magedov, I. V., Kireev, A. S., & Kornienko, A. V. (2006). One Step Three-Component Synthesis of Pyridines and 1,4-Dihydropyridines with Manifold Medicinal Utility. Org. Lett, 8(899).

Kireev, A. S., Manpadi, M., & Kornienko, A. V. (2006). Selectivity Guidelines and a Reductive Elimination-Based Model for Predicting the Stereochemical Course of Conjugate Addition Reactions of Organocuprates to g-Alkoxy-a,b-Enoates. J. Org. Chem, 71(2630).

Daniels, A. L., van Slambrouck, S., Lee, R. L., Arguello, T. S., Browning, J., Pullin, M. J., … Steelant, W. F. A. (2006). Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro. Oncology Reports, 15(1327).

Kireev, A. S., Nadein, O. N., Agustin, V. J., Bush, N. E., Evidente, A., Manpadi, M., … Kornienko, A. V. (2006). Synthesis and Biological Evaluation of Aromatic Analogues of Conduritol F, L-chiro-Inositol and Dihydroconduritol F Structurally Related to the Amaryllidaceae Anticancer Constituents. J. Org. Chem, 71(5694).

Evdokimov, N. M., Kireev, A. S., Yakovenko, A. A., Antipin, M. Y., Magedov, I. V., & Kornienko, A. V. (2006). Convenient One-Step Synthesis of a Medicinally Relevant Benzopyranopyridine System. Tetrahedron Lett, 47(9309).

Rastogi, S. K., & Kornienko, A. V. (2006). A solution to the stereochemical problems posed by amaryllidaceae constituents using a highly syn-selective arylcuprate conjugate addition to g-amino and g-carbamato-a,b-enoates. Tetrahedron: Asymmetry, 17(3170).

Kireev, A. S., Breithaupt, A. T., Collins, W., Nedein, O. N., & Kornienko, A. V. (2005). Enantiodivergent Formal Synthesis of (+)- and (-)-Cyclophellitol Based on the Latent Symmetry Concept. J. Org. Chem, 70(742).

Manpadi, M., & Kornienko, A. V. (2005). Highly anti selective conjugate addition of arylcuprates to a ?-alkoxy-?,?-enoate. A new method to address stereochemical challenges presented by Amaryllidaceae alkaloids. Tetrahedron Lett, 46(4433).

Nadein, O. N., & Kornienko, A. V. (2004). An Approach to Pancratistatins via Ring-Closing Metathesis: Efficient Synthesis of Novel 1-Aryl-1-deoxyconduritols F. Org. Lett, 6(831).

Hanessian, S., Kornienko, A. V., & Swayze, E. E. (2003). Probing the functional requirements of the L-haba side-chain of amikacin – Synthesis, 16S A-Site rRNA binding, and antibacterial activity. Tetrahedron, 59(995).

Hanessian, S., Tremblay, M., Kornienko, A. V., & Moitessier, N. (2001). Design, modeling and synthesis of functionalized paromamine analogs. Tetrahedron, 57(3255).

Kornienko, A. V., & d’Alarcao, M. (1999). Synthesis of Cyclitols via Ring-Closing Metathesis. Tetrahedron: Asymmetry, 10(827).

Kornienko, A. V., Turner, D. I., Jaworek, C. H., & d’Alarcao, M. (1998). Practical Synthesis of a Differentially Protected myo-Inositol. Tetrahedron: Asymmetry, 9(2783).

Kornienko, A. V., Marnera, G., & d’Alarcao, M. (1998). Synthesis of a Jojoba Bean Disaccharide. Carbohydr. Res, 310(141).

Kornienko, A. V., & d’Alarcao, M. (1997). Enantiospecific Synthesis of a Differentially Protected L-chiro-Inositol from D-Xylose. Tetrahedron Lett, 38(6497).

Magedov, I. V., Kornienko, A. V., Zotova, T. O., & Drozd, V. N. (1995). A New Convenient Method to Obtain Pyrroles from Tertiary N-Allylthioamides. Tetrahedron Lett, 36(4619).