Faculty Profile for Dr. Alexander Vladimir Kornienko

profile photo for Dr. Alexander Vladimir Kornienko
Dr. Alexander Vladimir Kornienko
Professor — Chemistry and Biochemistry
CHEM 319
phone: (512) 245-3632
Scholarly/Creative Work
Awards
Grants
Service

Biography Section

Biography and Education

 Postdoctoral Fellowship, Université de Montréal, Canada (Prof. Stephen Hanessian), 1999–2001
Ph.D. in Chemistry, Tufts University, Boston, USA (Prof. Marc d’Alarcao) 1994–1999
B.S in Chemical Engineering, Mendeleev University, Moscow, Russia, 1989–1994

Research Interests

 Synthetic Organic Chemistry (total synthesis and methodology)
Chemical Biology (focus on cancer signaling and death pathways)
Medicinal Chemistry (rational drug design and library screening)
Natural Product Chemistry (isolation, structure elucidation and analogue synthesis)

Selected Scholarly/Creative Work

  • Bretin, L., Husiev, Y., Ramu, V., Zhang, L., Hakkennes, M., Abyar, S., … Bonnet, S. (2024). Red-Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage. Angewandte Chemie International Edition English, e202316425.
  • Aksenov, D., Smith, J., Aksenov, A., Prityko, L., Aksenov, N., Kuzminov, I., … Kornienko, A. V. (2024). 2-(3-Indolyl)acetamides and their oxazoline analogues: Anticancer SAR study. Bioorganic and Medicinal Chemistry Letters, 102, 129681.
  • van der Westhuyzen, A., Ashraf, N., Conradie, D., Loots, L., Kaschula, C., Pelly, S., … van Otterlo, W. (2024). Improved rigidin-inspired antiproliferative agents with modifications on the 7-deazahypoxanthine C7/C8 ring systems. Journal of Medicinal Chemistry, 67, 9950–9975.
  • Maslivetc, V., Hasan, N., Boari, A., Zejnelovski, A., Evidente, A., Sun, D., & Kornienko, A. V. (2024). Ophiobolin A derivatives with enhanced activities under tumor-relevant acidic conditions. Bioorganic and Medicinal Chemistry Letters, 110, 129863.
  • Ingels, A., Scott, R., Hooper, A., van der Westhuyzen, A., Wagh, S., de Meester, J., … Mathieu, V. (2024). New hemisynthetic derivatives of sphaeropsidin phytotoxins triggering severe endoplasmic reticulum swelling in cancer cells. Scientific Reports, 14, 14674.

Selected Awards

  • Award / Honor Recipient: Holder of Denise M. Trauth Endowed Presidential Research Professorship, Texas State University. 2021 - 2024
  • Award / Honor Recipient: 2024 Presidential Distinction Award, Texas State University. August 2024
  • Award / Honor Recipient: Presidential Award for Scholarly/Creative Activities, President. January 31, 2016 - August 25, 2016

Selected Grants

  • Lewis, Karen A (Principal), Kerwin, Sean Michael (Co-Principal), Whitten, Steven T (Co-Principal), Kornienko, Alexander Vladimir (Supporting), Peterson, Ryan Loren (Supporting), Xue, Xiaoyu (Supporting). MRI: Acquisition of Automated Isothermal Titration Calorimeter for Biophysical Research at Texas State University, National Science Foundation, Federal, $262280. (Submitted: January 19, 2022, Funded: September 1, 2022 - August 31, 2025). Grant.
  • Lewis, Karen A (Principal), Luxford, Cynthia J (Co-Principal), Wheeler, Brittany Marie (Co-Principal), Webre, Whitney Ann (Co-Principal), Holland, Cory Lee (Co-Principal), Betancourt, Tania (Supporting), Brittain, William J (Supporting), Hudnall, Todd W (Supporting), Irvin, Jennifer A (Supporting), Kerwin, Sean Michael (Supporting), Kornienko, Alexander Vladimir (Supporting), Peterson, Ryan Loren (Supporting), Rhodes, Christopher Peter (Supporting). REU Site: A Chemistry REU on Molecular Innovation and Exploration (CheMIE), National Science Foundation, Federal, $378188. (Submitted: August 25, 2021, Funded: April 15, 2022 - Present). Grant.
  • Du, Liqin (Principal), Kornienko, Alexander (Other), Houhgton, Peter (Other). Discovery of new differentiation agents for neuroblastoma therapy, National Institute of Health, NCI, R15, resubmissiom, Federal, $461574. (Funded: August 1, 2017 - July 31, 2020). Grant.
  • Kornienko, Alexander Vladimir (Co-Principal), Romo, Daniel (Principal). Pharmacophore-Directed Retrosynthesis Applied to Bioactive Natural Products Informing Mechanism of Action Studies, NIH, Federal, $2250000. (Submitted: January 2024, Funded: January 2025 - January 2030). Grant.
  • Hudnall, Todd W (Principal), Kerwin, Sean Michael (Co-Principal), Peterson, Ryan Loren (Co-Principal), Shi, Xijun (Co-Principal), Schilter, David (Co-Principal), Haque, Ariful (Supporting), Droopad, Ravindranath (Supporting), Chen, Yihong (Supporting), Brittain, Bill (Supporting), Geerts, Wilhelmus J (Supporting), Kornienko, Alexander Vladimir (Supporting). MRI: Acquisition of a Single Crystal X-ray Diffractometer to Advance Structural Analysis in Chemical, Biochemical, and Material Sciences at Texas State University, National Science Foundation, Federal, $485000. (Submitted: November 15, 2023, Funded: August 15, 2024 - July 31, 2027). Grant.

Selected Service Activities

Member
IMBC Faculty Search Committe
September 2024-Present
Member
IMBC Admission Committee
July 2024-Present
Member
College Review Committee
2023-Present
Chair
Personnel Committee
2022-Present
Member
Graduate Admission Committee
2020-Present