Biography and education
I am a fish physiologist and endocrinologist with a decade of research experience focused on the intriguing realm of pheromones and chemical communication in fish. My primary area of study at Texas State University centers on olfactory processes in vertebrates. Specifically, I investigate the effects of environmental pollutants, including nitrite, viruses, and bacteria, on the sense of smell. Additionally, I aim to uncover how external chemical signals—comprising pheromones, chemical cues, and pathogens—are
detected by the olfactory epithelium, how this information is integrated into the brain, and how it subsequently activates the endocrine axis to initiate specific physiological processes like reproduction and behavior.
To achieve my research goals, I employ a range of refined techniques, including electrophysiology (utilizing electro-olfactogram and electro-encephalogram), protein biochemistry (to explore the morphology and physiology of components within the hypothalamus-pituitary-gland axis), steroid analysis (including radioimmunoassay, ELISA, and liquid chromatography-mass spectrometry), as well as histology (through
immunohistochemistry and in situ hybridization) and molecular procedures (such as transcriptomics, qPCR, and dPCR). I chose to specialize in this field to deepen my understanding of vertebrate olfaction, ultimately providing new tools to manage fish populations and address environmental health issues.
During my career, I encountered inspirational mentors and realized the importance of intentional mentoring. Since then, I committed to learning and continually developing mentoring best practices that guide my students to success. I started my mentor activities in 2009 and have been a mentor at Texas State since 2016.
detected by the olfactory epithelium, how this information is integrated into the brain, and how it subsequently activates the endocrine axis to initiate specific physiological processes like reproduction and behavior.
To achieve my research goals, I employ a range of refined techniques, including electrophysiology (utilizing electro-olfactogram and electro-encephalogram), protein biochemistry (to explore the morphology and physiology of components within the hypothalamus-pituitary-gland axis), steroid analysis (including radioimmunoassay, ELISA, and liquid chromatography-mass spectrometry), as well as histology (through
immunohistochemistry and in situ hybridization) and molecular procedures (such as transcriptomics, qPCR, and dPCR). I chose to specialize in this field to deepen my understanding of vertebrate olfaction, ultimately providing new tools to manage fish populations and address environmental health issues.
During my career, I encountered inspirational mentors and realized the importance of intentional mentoring. Since then, I committed to learning and continually developing mentoring best practices that guide my students to success. I started my mentor activities in 2009 and have been a mentor at Texas State since 2016.
Teaching Interests
Research Interests
Featured grants
- Huertas Pau, Maria del Mar. A portal into the brain: olfactory crypt neurons modulate brain viral immunity in teleost, National Science Fundation, Federal, $625000. (Submitted: 2017, Funded: August 20, 2018 - October 19, 2021). Grant.
- Huertas Pau, Maria del Mar (Principal). Support for Research Excellence (SuRE) Program (R16). Maternal transfer factors and offspring development defects induced by nitrite, NIH, Federal, $592844. (Funded: 2024 - 2028). Grant.
- Huertas Pau, Maria del Mar. Run to R1 postdoctoral program, TXST, Texas State University, $100000. (Funded: 2023 - 2025). Grant.
- Huertas Pau, Maria del Mar. EAGER: Environmental nitrite is a nitric oxide donor that modulates fish olfactory function, National Science Fundation, Federal, $295000. (Submitted: August 2022, Funded: January 2023 - January 2025). Grant.
- Huertas Pau, Maria del Mar. SEED: Exploring novel fish cultures for small and midscale aquaponics system, USDA, Federal, $268217. (Submitted: August 2022, Funded: January 2023 - January 2025). Grant.

Featured scholarly/creative works
- Buchinger, T., Anne, S. M., Skye, F., Brant, C. O., Huertas Pau, M. del M., Li, K., … Li, W. (2020). A pheromone antagonist liberates female sea lamprey from a sensory trap to enable reliable communication. PNAS. https://doi.org/10.1073/pnas.1921394117
- Sepahi, A., Kraus, A., Casadei, E., Johnston, C. A., Galindo-Villegas, J., Kelly, C., … Salinas, I. (2019). Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner. Proceedings of the National Academy of Sciences, 201900083. https://doi.org/10.1073/pnas.1900083116
- Li, K., Brant, C., Huertas Pau, M. del M., Hessler, E., Mezei, G., Scott, A. M., … Li, W. (2018). Fatty-acid derivative acts as a sea lamprey migratory pheromone. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1803169115
- Huertas Pau, M. del M., & Billah, M. M. (2023). Pathogen odors elicit distinct neurosteroid and behavioral responses in Rainbow trout (Oncorhynchus mykiss). Physiology, 38(S1).
- Franklin, A., Restrepo, N., Carlos-Shanley, C., & Huertas Pau, M. del M. (2023). Bacteria and nitrite change smelling ability of catfish.
Featured awards
- Award / Honor Recipient: Research Grant Millionaire awards., College of Science and Engineering at TXST. 2025
- Award / Honor Recipient: Sponsored guest Allen Foundation and Kavli Institute, Allen Foundation and Kavli Institute. 2025
- Award / Honor Recipient: Research Grant Millionaire awards., College of Science and Engineering at TXST. 2024
- Award / Honor Recipient: Excellence in Scholarly/Creative activities, Texas State University. 2022
- Award / Honor Recipient: STEM Undergraduate Research Experience (SURE) (Mentor), Texas State University. June 2018 - January 2021

Featured service activities
- Undergraduate Advisor
USDA LEADING program
- Graduate Advisor
STEMINITAS
- Speaker
STEM sisters Speakers (NISD)
- Chair
JEDI (Committee of, Justice, Equity, Diversity and Inclusion in the Biolog
- Volunteer
Sigths and Sounds
- University Mentor
U-Rise program
