Faculty Profiles

Kerwin, S. M. (2025). Introduction to non-canonical DNA using 3D printed models. Abstracts of Papers, 269th ACS National Meeting, CHED-98.

Myhre, M. W., Das, M. K., Williams, E. P., David, W. M., & Kerwin, S. M. (2025). From triads to tools: A Comprehensive Review of the Expanding Landscape of G-Triplex Structures. Molecules, 30, 4303. Retrieved from https://doi.org/10.3390/molecules30214303

Tho, C., Kerwin, S. M., Jamnongtanachot, P., Vongsutilers, V., & Tuesuwan, B. (2025). Revisiting ligand-exchange chromatography for valsartan chiral analysis using a conventional non-chiral column. J. Pharm. Sci., 114, 103797. https://doi.org/10.1016/j.xphs.2025.103797

Saucedo, A., Muppidi, S., Smith, J. L., Jemal, M., Mesa-Diaz, N. L., Vernaza, A., … Kerwin, S. M. (2025). Caffeic acid phenethyl amide and analogues as anticancer agents against neuroblastoma. Book of Abstracts of the 269th ACS National Meeting & Exposition.

Kerwin, S. M., & Subbarao, M. (2024). Water-Mediated Synthesis of (E)-3-(1-methyl-1H-benzo[d]imidazol-5-yl)-N-phenethylacrylamide, a Caffeic Acid Phenethyl Amide analogue. MolBank, M1915. Retrieved from https://doi.org/10.3390/M1915

Das, M. K., Williams, E. P., Myhre, M. W., David, W. M., & Kerwin, S. M. (2024). Calcium-Dependent Chemiluminescence Catalyzed by a Truncated c-MYC Promoter G-Triplex DNA. Molecules, 29, 4457. Retrieved from https://doi.org/10.3390/molecules29184457

Saucedo, A., Subbarao, M., Jemal, M. J., Mesa-Diaz, N. L., Smith, J. L., Vernaza, A., … Kerwin, S. M. (2024). Flow and On-Water Synthesis and Cancer Cell Cytotoxicity of Caffeic Acid Phenethyl Amide (CAPA) Derivatives. Int J Mol Sci., 25(15), 1–11. https://doi.org/10.3390/genes15101268

Kerwin, S. M., David, W. M., Myhre, M. W., & Das, M. K. (2024). Investigations of G-Triplex DNA formation by Surface Plasmon Resonance. Journal of Biological Chemistry, 300(3), 106585. Retrieved from https://www.jbc.org/article/S0021-9258(24)01058-5/fulltext

Jewett, A., Bondoc, J., Gilbreath, B., Reinus, B., & Kerwin, S. M. (2022). Spirocyclic Products via Carbene Intermediates from Thermolysis of 1,2-Dialkynylpyrrole and 1,2-Diethynylimidzoles. SynLett, 33(07), 674-678.

Yadav, G., Kumar, S., Kumar, D., Kataria, R., Laroche, C., & Kerwin, S. M. (2022). Phenyliodine(III) diacetate-mediated dearomatization of 2-(2-hydroxyaryl)benzoxazoles and 2-(2-hydroxyaryl)benzothiazoles: Regio- and stereoselective synthesis of tetramethoxycyclohexenones and bicyclo[2.2.2]octenones. Journal of Molecular Structure, 1266, 133520.

Schwartz, Z. T., Theisen, P. D., Bjornstal, O. T., Rodebaugh, M., Jemal, M. A., Lee, D., … Kerwin, S. M. (2022). Scalable Synthesis and Cancer Cell Cytotoxicity of Rooperol and Analogues. Molecules, 27, 1–17. https://doi.org/10.3390/molecules27061792

Reinus, B., & Kerwin, S. M. (2019). N-Alkynyl Pyrrole Based Total Synthesis of Shensongine A. Synthesis, 51, 4085–4105.

McBrayer, D., Schoonover, M., Long, K., Escobedo, R., & Kerwin, S. M. (2019). N-Methylmesoporphyrin IX Exhibits G-Quadruplex Specific Photocleavage Activity. ChemBioChem, 20(15), 1924–1927.

Kerwin, S. M. (2019). Flexible and modular 3D‐printed peptide models. Chemistry and Molecular Biology Education, 47(4), 432–437. https://doi.org/10.1002/bmb.21250

Kerwin, S. M., & Bohanon, A. L. (2019). Stability Studies of Rooperol and Analogues by In Vitro Metabolism with HPLC/MS Detection. FASEB Journal, 33(1S).

Kerwin, S. M., Long, K., & David, W. M. (2019). Non-Canonical DNA in the c-Myc Hotspot Region. FASEB Journal, 33(1S).

Al-Der, C. C., David, W. M., Tippayasak, K., Tuesuwan, B., & Kerwin, S. M. (2019). G-Triplex DNA Formation Determined by SPR and Native Agarose Gel Electrophoresis. FASEB Journal, 33(1S).

Kerwin, S. M., Bracey, H., Navapan, N., Tippayasak, K., Lee, D., Blanton, C., … Tuesuwan, B. (2019). Sequence and Environmental Effects on the Formation of G-triplex DNA. FASEB Journal, 32(1), 647.

Kerwin, S. M., Bracey, H., Navapan, N., Tippayasak, K., Al-Der, C., Baqdounes, Y., … Tuesuwan, B. (2019). Spectroscopic, Gel Electrophoretic, and Surface Plasmon Resonance Characterization of G-Triplex DNA Formation. FASEB Journal, 32(1), 775.4.

Jemal, M. A., Schwartz, Z. T., Zhao, Z., Du, L., Du, L., Du, L. D., … Du, L. M. (2019). Overcoming the Rapid Metabolism of the Promising Anticancer Natural Product Rooperol. FASEB Journal, 33(No.1 Suppl). Retrieved from https://www.fasebj.org/doi/abs/10.1096/fasebj.2019.33.1_supplement.634.5

Reinus, B., & Kerwin, S. M. (2019). Preparation and Utility of N-Alkynyl Azoles in Synthesis. Molecules, 24(3).

Kerwin, S. M., Long, K., & David, W. M. (2018). Non-Canonical DNA in the c-Myc Hotspot Region. Federation of American Societies for Experimental Biology Journal, 31(1), S522.1.

Bracey, H. E., Navapan, N., Tippayasak, K., Blanton, D., Lee, D., del Mundo, I., … Kerwin, S. M. (2018). Targeting the G-Triplex Intermediate in G-Quadruplex DNA Folding for Potential Chemoprevention Applications. Federation of American Societies for Experimental Biology, 31(1), S647.7.

Bondoc, J., & Kerwin, S. M. (2018). Computational Analysis of 1,2-Dialkynylpyrroles. Federation of Societies for Experimental Biology Journal, 31(1), S105.

Schwartz, Z., & Kerwin, S. M. (2018). Scalable synthesis of rooperol and analogues. Abstracts of Papers, 256th ACS National Meeting, CHED-297.

del Mundo, I. M. A., Zewail-Foote, M., Kerwin, S. M., & Vasquez, K. M. (2017). Alternative DNA structure formation in the mutagenic human c-MYC promoter. Nucleic Acids Research, 45(8), 4929–4943. https://doi.org/10.1093/nar/gkx100

Reinus, B. J., & Kerwin, S. M. (2017). A Copper-Catalyzed N-Alkynylation Route to 2-Substituted N-Alkynyl Pyrroles and Their Cyclization into Pyrrolo[2,1-c]oxazin-1-ones: A Formal Total Synthesis of Peramine. Synthesis, 49(11), 2544–2554. https://doi.org/10.1055/s-0036-1588736

Kerwin, S. M., & David, W. M. (2015). G-Quadruplex Dynamics:  Assays for Intramolecular G-Quadruplex Helicases and Inhibitors. In D. Monchaud (Ed.), Biological & Therapeutic Applications ofDNA- and RNA-Quadruplexes (pp. 85–99). London, England: Future Science.

McBrayer, D., & Kerwin, S. M. (2015). Synthesis and Evaluation of a Rationally Designed Click-based Library for G-Quadruplex Selective DNA Photocleavage. Molecules, 20(9), 16446–16465.

McBrayer, D., & Kerwin, S. M. (2015). Selective G-quadruplex DNA photocleavage agents: N-methyl-mesoporphyrin IX. Abstracts of Papers of the American Chemical Society, (249), BIOL-33.

Yang, J., Bowman, P. D., Kerwin, S. M., & Stavchansky, S. (2014). Development and validation of an LCMS method to determine the pharmacokinetic profiles of caffeic acid phenethyl amide and caffeic acid phenethyl ester in Sprague-Dawley rats. Biomed. Chromatogr., (28), 241–246.

Laroche, C., Gilbreath, B., & Kerwin, S. M. (2014). Exploring the synthetic utility of 1-alkynylimidazoles:  Regiocontrolled cyclization to diverse imidazoazines and imidazoazoles. Tetrahedron, (70), 4534–4539.

Li, J., Kaoud, T. S., LeViuex, J., Gilbreath, B., Moharana, S., Dalby, K. N., & Kerwin, S. M. (2013). A fluorescence-based assay for p38 alpha docking site binders: Identification of the Hypoxis natural product rooperol as a novel p38 alpha kinase inhibitor. ChemBioChem, (14), 66–71.

McBrayer, D., Schoonover, M. L., & Kerwin, S. M. (2013). Selective G-quadruplex DNA photocleavage agents:  N-methyl-mesoporphyrin IX. Abstracts of Papers of the American Chemical Society, (245), BIOL-33.

Li, J., Kaoud, T. S., Levieux, J., Gilbreath, B., Moharana, S., Dalby, K. N., & Kerwin, S. M. (2013). Assay for p38a recruitment site binders: Identification of rooperol as a novel p38a kinase inhibitor. Abstracts of Papers of the American Chemical Society, (245), MEDI-58.

Yang, J., Kerwin, S. M., Bowman, P. P., & Stavchansky, S. (2012). Stability of Caffeic Acid Phenethyl Amide (CAPA) in Rat Plasma. Biomed. Chromatogr., (26), 594–598.

Schoonover, M., & Kerwin, S. M. (2012). G-Quadruplex DNA Cleavage Preference and Identification of a Perylene Diimide G-Quadruplex Photocleavage Agent Using a Rapid Fluorescent Assay. Bioorg. Med. Chem., (20), 6904–6918.

Omar, M. A., Shaker, Y. M., Galal, S. A., Ali, M. M., Kerwin, S. M., Li, J., … El Diwani, H. I. (2012). Synthesis and docking studies of novel antitumor benzimidazoles. Bioorg. Med. Chem., (20), 6989–7001.

Kerwin, S. M. (2012). Natural Products Research:  Future Trends. Nat. Prod. Chem. Res., 1, e101.

Kerwin, S. M., & Schoonover, M. (2011). A Fluorescence-based G-Quadruplex DNA Cleavage Assay. In R. Sheardy (Ed.), Frontiers in Nucleic Acids (pp. 13–32). Washington, United States: ACS.

Kerwin, S. M., Laroche, C., & Gilbreath, B. (2011). Synthetic applications of alkynylimidazoles and generality of the dialkynylimidazole to carbene thermal rearrangement. Abstracts of Papers of the American Chemical Society, (241), ORGN-696.

Li, J., Kaoud, T. S., Dalby, K. N., & Kerwin, S. M. (2011). Targeting kinase docking sites: A fluorescence-based assay for p38-alpha inhibitors targeting a substrate binding site. Abstracts of Papers of the American Chemical Society, (241), MEDI-261.

David, W. M., Kerwin, S. M., & Decker, M. J. (2011). Inhibition of DNA helicase activity determined by SPR. FASEB J., (25), 498.2.

Wang, X., Stavchansky, S., Kerwin, S. M., & Bowman, P. D. (2010). Structure-activity Relationships in the Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Fluorinated Derivatives: Effects on Heme Oxygenase-1 Induction and Antioxidant Activities. Eur. J. Pharmacol., (635), 16–22.

Laroche, C., Li, J., Golzales, C., David, W. M., & Kerwin, S. M. (2010). Cyclization Kinetics and Biological Evaluation of an Anticancer 1,2-Dialkynylimidazole. Org. Biomol. Chem., (8), 1535–1539.

Yang, J., Marriner, G. A., Wang, X., Bowman, P. D., Kerwin, S. M., & Stavchansky, S. (2010). Synthesis of a Series of Caffeic Acid Phenethyl Amide (CAPE) Fluorinated Derivatives: Comparison of Cytoprotective Effects to Caffeic Acid Phenethyl Ester (CAPE). Bioorg. Med. Chem., (18), 5032–5038.

Kerwin, S. M. (2010). ChemBioOffice Ultra. J. Am. Chem. Soc., (132), 2466–2467.

Kerwin, S. M. (2009). DNA Damage Due to Diradical-Generating Cyclizations. In M. Greenberg (Ed.), Radical and  Radical Ion Reactivity in Nucleic Acid Chemistry (pp. 389–419). New York City, New York, United States: Wiley.

Plyler, J., Jasheway, K., Karr, J., Brennan, J. S., Kerwin, S. M., & David, W. M. (2009). Real-time Investigation of SV40 Large T-antigen Helicase Activity Using Surface Plasmon Resonance. Cell Biochem. Biophys, (53), 43–52.

Galal, S. A., Hagab, K. H., Kassab, A. S., Rodriguez, M., Kerwin, S. M., El-Khamry, A.-M. A., & Diwani, H. I. (2009). New Transition Metal Ion Complexes with Benzimidazole-5-Carboxylic Acid Hydrazides with Antitumor Activity. Eur. J. Med. Chem., (44), 1500–1508.

Mariner, W. A., & Kerwin, S. M. (2009). An Improved Synthesis of N’-Nitroso-Nornicotine-5’-Acetate. J. Org. Chem., (74), 2891–2892.

Laroche, C., Li, J., & Kerwin, S. M. (2009). Lithiation and Functionalization of N-Alkynylimidazoles at the 2-Position. Tetrahedron Lett., (50), 5194–5197.

Wang, X., Pang, J., Mafucci, J. A., Newman, R. A., Kerwin, S. M., Bowman, P. D., & Stavchansky, S. (2009). Pharmacokinetics of Caffeic Acid Phenethyl Ester and its Catechol-Ring Fluorinated Derivative Following Intravenous Administration to Rats. Biopharm. Drug Disp., (30), 221–228.

Laroche, C., & Kerwin, S. M. (2009). Efficient, Regioselective Access to Bicyclic Imidazo[1,2-x]- Heterocycles via Gold and Base Promoted Cyclization of 1-Alkynylimidazoles. J. Org. Chem., (74), 9229–9232.

Li, J., Kaoud, T. S., Laroche, C., Dalby, K. N., & Kerwin, S. M. (2009). Synthesis and Biological Evaluation of p53 alpha Kinase-Targeting Dialkynylimidazoles. Bioorg. Med. Chem. Lett., (19), 6293–6297.

Kerwin, S. M. (2009). Cytotoxic 1,2-Dialkynylimidazole-Based Aza-Enediynes:  Aza-Bergman Rearrangement Rates do not Predict Cytotoxicity. JACS Select 2009, (4). Retrieved from pubs.acs.org/JACSbeta/jvi/issue4.html

Kerwin, S. M. (2009). Commentary on “Effect of O6-Methylguanine on the Stability of G-Quadruplex DNA.” JACS Select 2009, (4). Retrieved from pubs.acs.org/JACSbeta/jvi/issue4.html

Yang, J., Kerwin, S. M., Wang, X., Stavchansky, S., Bynum, J., & Bowman, P. (2009). Structure activity relationships of caffeic acid phenethyl ester (CAPE) and its amide derivative caffeic acid phenethyl amide (CAPA) against oxidant stress in human endothelial cells. The FASEB Journal, 23(S1). https://doi.org/10.1096/fasebj.23.1_supplement.937.8

McKee, M. L., & Kerwin, S. M. (2008). Synthesis, Metal Ion Binding, and Biological Evaluation of New Anticancer 2-(2’-Hydroxyphenyl)benzoxazole Analogs of UK-1. Bioorg. Med. Chem., (16), 1175–1783.

Mazzitelli, C. L., Rodriguez, M., Kerwin, S. M., & Brodbelt, J. S. (2008). Evaluation of Metal-Mediated DNA Binding of Benzoxazole Ligands by Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom, (19), 209–218.

Tuesuwan, B., Kern, J. T., Thomas, P. W., Rodriguez, M. L., Li, J., David, W. M., & Kerwin, S. M. (2008). Simian Virus 40 Large T-antigen G-Quadruplex DNA Helicase Inhibition by G-Quadruplex DNA-Interactive Agents. Biochemistry, (47), 1896–1909.

Wang, X., Pang, J., Newman, R. A., Kerwin, S. M., Bowman, P., & Stavchansky, S. A. (2008). Quantitative Determination of Fluorinated Caffeic Acid Phenethyl Ester Derivative from Rat Blood Plasma by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry. J. Chromatogr. B., (867), 138–143.

Wang, X., Stavchansky, S. A., Zhao, B., Bynum, J. A., Kerwin, S. M., & Bowman, P. (2008). Cytoprotection of Human Endothelial Cells from Menadione Cytotoxicity by Caffeic Acid Phenethyl Ester (CAPE):  The Role of Heme Oxygenase-1. Eur. J. Pharmacol., (591), 28–35.

Laroche, C., Li, J., Freyer, M. S., & Kerwin, S. M. (2008). Coupling Reactions of Bromoalkynes with Imidazoles Mediated by Copper Salts:  Synthesis of Novel N-Alkynylimidazoles. J. Org. Chem., (73), 6462–6465.

Mandal, S., Li, W. T., Bai, Y., Robertus, J. D., & Kerwin, S. M. (2008). Synthesis of 2-Substituted 9-Oxa-guanines [5-Amino-oxazolo[5,4-d]pyrimidin-7(6H)-ones] and 9-Oxa-2-thio-xanthines [5-Mercapto-oxazolo[5,4-d]pyrimidin-7(6H)-ones]. J. Org. Chem., 4(26), 1–5.

Laroche, C., & Kerwin, S. M. (2008). Experimental and DFT studies of the thermal rearrangement of 1,2-dialkynylimidazoles. Abstracts of Papers of the American Chemical Society, (235), ORGN-154.

Laroche, C., McKee, M. L., & Kerwin, S. M. (2008). 1,2-Dialkynylimidazoles: Anticancer aza-enediynes. Abstracts of Papers of the American Chemical Society, (235), MEDI-106.

David, W. M., Karr, J., Brennan, J., Jasheway, K., & Kerwin, S. M. (2008). Real-time investigation of SV40 T-antigen helicase activity using SPR. Abstracts of Papers of the American Chemical Society, (235), BIOL-077.

Wang, X., Bowman, P., Kerwin, S. M., & Stavchansky, S. A. (2007). Stability of Caffeic Acid Phenethyl Ester (CAPE) and its Fluorinated Derivative (FCAPE) in Rat Plasma. Biomed. Chromatogr., (21), 343–350.

Wang, X., Bowman, P. D., Kerwin, S. M., & Stavchansky, S. (2007). Cytoprotection of human endothelial cells from oxidative stress by caffeic acid phenethyl ester and its fluorinated derivatives: effects on heme oxygenase-1 and direct antioxidant activities. Pharmaceutical Sciences World Conference.

Wang, X., Bowman, P. D., Kerwin, S. M., & Stavchansky, S. A. (2007). Structure activity relationships of caffeic acid phenethyl ester (CAPE) and synthetic derivatives in cytoprotection against menadione (MD)-induced injury: The role of heme oxygenase-1(HO-1) induction versus antioxidant activity. American Association of Pharmaceutical Scientists Annual Meeting.

Nadipuram, A. K., & Kerwin, S. M. (2006). Intra- and Intermolecular Trapping of Cyclopentapyrazine Carbenes Derived from 1,2-Dialkynylimidazoles. Tetrahedron Lett., (47), 353–356.

Nadipuram, A. K., & Kerwin, S. M. (2006). Thermal Cyclization of 1,2-Dialkynyl-imidazoles to Imidazo[1,2-a]pyridines. Tetrahedron, (62), 3798–3808.

Wang, X., Stavchansky, S. A., Bowman, P., & Kerwin, S. M. (2006). Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Catechol Ring-Fluorinated CAPE Derivatives against Menadione-Induced Oxidative Stress in Human Endothelial Cells. Bioorg. Med. Chem., (14), 4879–4887.

Feng, L., Zhang, A., & Kerwin, S. M. (2006). Enediynes from Aza-enediynes:  C,N-Dialkynyl Imines Undergo Both Aza-Bergman Rearrangement and Conversion to Enediynes and Fumaronitriles. Org. Lett., (8), 1983–1986.

Tuesuwan, B., & Kerwin, S. M. (2006). 2-Alkynyl-N-Propargyl Pyridinium Salts:  Pyridinium-Based Heterocyclic Skipped-Aza-Enediynes that Cleave DNA by Deoxyribosyl Hydrogen Atom Abstraction and Guanine Oxidation. Biochemistry, (45), 7265–7276.

Mazzitelli, C., Rodriguez, M., Kern, J. T., & Kerwin, S. M. (2006). Evaluation of Binding of Perylene Diimide and Benzannulated Perylene Diimide Ligands To DNA by Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom, (17), 593–604.

Sherman, C. L., Pierce, S., Brodbelt, J. S., Tuesuwan, B., & Kerwin, S. M. (2006). Identification of the Adduct Between a 4-Aza-3-ene-1,6-diyne and DNA Using Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom, (17), 1342–1352.

Rodriguez, M. L., & Kerwin, S. M. (2006). Synthesis, metal binding, and cytotoxicity of UK-1 analogs. Abstracts of Papers of the American Chemical Society, (232), MEDI-042.

Tuesuwan, B., & Kerwin, S. M. (2006). DNA cleavage chemistry of pyridine-based heterocyclic skipped aza-enediynes: Deoxyribosyl hydrogen atom abstraction and guanine oxidation. Abstracts of Papers of the American Chemical Society, (232), MEDI-033.

Kerwin, S. M., Tuesuwan, B., Rodriguez, M., & David, W. M. (2006). SV-40 T-antigen helicase inhibition by G-quadruplex interactive compounds. Abstracts of Papers of the American Chemical Society, (232), MEDI-015.

Tuesuwan, B., & Kerwin, S. M. (2006). Targeting SV-40 large T-antigen G-quadruplex DNA helicase activity by G-quadruplex interactive agents. Abstracts, 62nd Southwest Regional Meeting of the American Chemical Society.

Wang, X., Bowman, P. D., Kerwin, S. M., & Stavchansky, S. (2006). Kinetics of hydrolysis of caffeic acid phenethyl ester (CAPE) and its fluorinated derivative (FCAPE) in rat plasma. American Association of Pharmaceutical Scientists Annual Meeting.

Pothukuchy, A., Mazzitelli, C., Rodriguez, M. L., Tuesuwan, B., Salazar, M., Brodbelt, J. S., & Kerwin, S. M. (2005). Duplex and Quadruplex DNA binding and Photocleavage by Trioxatriangulenium Ion. Biochemistry, (44), 2163–2172.

Kerwin, S. M. (2005). Review of  “eHiTS 5.1.6.” J. Am. Chem. Soc., (127), 8899–8900.

Wang, X., Bowman, P., Kerwin, S. M., & Stavchansky, S. (2005). Structure-Activity Relationships between Caffeic Acid Phenethyl Ester (CAPE) Derivatives and Cytoprotection of Human Endothelial Cells against Oxidative Stress: Role of Heme Oxygenase. Abstracts of the American Association of Pharmaceutical Scientists Annual Meeting, 2005.

Kerwin, S. M. (2005, June 1). eHiTS 5.1.6 SimBioSys Inc., 135 Queen’s Plate Drive, Unit 420, Toronto, Ontario M9W 6V1, Canada. http://simbiosys.ca/index.html. For pricing information, contact company. Journal of the American Chemical Society. American Chemical Society (ACS). https://doi.org/10.1021/ja041024z

Kerwin, S. M. (2004). Saponins with Anticancer and Chemoprevention Activity. Curr. Med. Chem. Anticancer Agents, (4), 263–272.

Oehlers, L., Mazzitelli, C., M Rodriguez, Kerwin, S. M., & Brodbelt, J. (2004). Evaluation of Complexes of DNA Duplexes and Novel Benzoxazoles and Benzimidazoles by Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spec., (15), 1593–1603.

Feng, L., Kumar, D., Birney, D., & Kerwin, S. M. (2004). alpha, 5-Didehydro-3-picoline Diradicals from Skipped Aza-Enediynes:  Computational and Trapping Studies of an Aza-Myers-Saito Cyclization. Org. Lett., (6), 2059–2062.

Kerwin, S. M. (2004). 5H-Cyclopentapyrazines from 1,2-Dialkynylimidazoles. Synlett, 1404–1408.

Feng, L., Kumar, D., & Kerwin, S. M. (2004). Alpha,5-didehydro-3-picoline diradicals from skipped aza-enediynes: Computational and trapping studies of an aza-Myers-Saito cyclization. Abstracts of Papers of the American Chemical Society, (228), ORGN-484.

Nadipuram, A. K., & Kerwin, S. M. (2004). Carbene intermediates from thermal rearrangements of 1,2-dialkynylimidazoles. Abstracts of Papers of the American Chemical Society, (228), ORGN-722.

Kerwin, S. M., Nadipuram, A., & Feng, L. (2004). Rearrangements of aza-enediynes and skipped aza-enediynes. Abstracts of Papers of the American Chemical Society, (228), ORGN-742.

Robertus, J. D., Sawyer, G., Schleit, J., Kerwin, S. M., Dilek, I., & Madal, S. (2004). The structure-based design of inhibitors to the cytotoxin ricin. Protein Sci., (13), 129–130.

Wang, X., Zhao, B., Bowman, P. D., Kerwin, S. M., & Stavchansky, S. (2004). Protection of human umbilical vein endothelial cells (HUVEC) against oxidative stress by caffeic acid phenethyl ester (CAPE) and derivatives:  role of heme oxygenase-1. Abstracts of the American Association of Pharmaceutical Scientists Annual Meeting 2004.

Wang, X., Kerwin, S. M., Zhao, B., Bowman, P. D., & Stavchansky, S. (2004). Synthesis of caffeic acid phenethyl ester (CAPE) derivatives. Abstracts of the American Association of Pharmaceutical Scientists Annual Meeting 2004.

Feng, L., Kumar, D., & Kerwin, S. M. (2003). An Extremely Facile Aza-Bergman Rearrangement of Sterically Unencumbered Acyclic 3-Aza-3-ene-1,5-diynes. J. Org. Chem., (68), 2234–2242.

Feng, L., & Kerwin, S. M. (2003). Isolation of a Cyclopropane-Containing Product from the Rearrangement of a 3-Aza-3-ene-1,5-diyne under Acid Catalysis. Tetrahedron Lett., (44), 3463–3466.

Feng, L., Kumar, D., & Kerwin, S. M. (2003). An extremely facile aza-Bergman cyclization of sterically unencumbered acyclic 3-aza-3-ene-1,5-diynes. Abstracts of Papers of the American Chemical Society, (225), MEDI-281.

Nadipuram, A. K., Kumar, D., & Kerwin, S. M. (2003). Synthesis and thermal cyclization of imidazole-based 3-aza-3-ene-1,5-diynes. Abstracts of Papers of the American Chemical Society, (225), MEDI-112.

Kerwin, S. M., Feng, L., Nadipuram, A., & Tuesuwan, B. (2003). Acyclic and heterocyclic aza-enediynes and skipped aza-enediynes. Abstracts of Papers of the American Chemical Society, (225), MEDI-010.

Kerwin, S. M., Thomas, P. W., Kern, J. T., Ravikumar, K. S., & Chen, G. (2002). Perylene Diimide G-Quadruplex DNA Binding Selectivity is Mediated by Ligand Aggregation. Bioorg. Med. Chem. Lett., (12), 447–450.

Miller, D. J., Ravikumar, K. S., Shen, H., Suh, J. K., Kerwin, S. M., & Robertus, J. (2002). Structure-Based Design and Characterization of Novel Platforms for Ricin and Shiga Toxin Inhibition. J. Med. Chem., (45), 90–98.

Tuntiwechapikul, W., David, W. M., Kumar, D., Salazar, M., & Kerwin, S. M. (2002). DNA Modification by 4-Aza-3-ene-1,6-diynes:  DNA Cleavage, pH-Dependent Cytosine-Specific Interactions, and Cancer Cell Cytotoxicity. Biochemistry, (41), 5283–5290.

David, W. M., Brodbelt, J., Kerwin, S. M., & Thompson, P. W. (2002). Investigation of Quadruplex Oligonucleotide-Drug Interactions by Electrospray Ionization-Mass Spectrometry. Anal. Chem., (74), 2029–2033.

Kumar, D., Jacob, M., Reynolds, M., & Kerwin, S. M. (2002). Synthesis and Evaluation of Anticancer Benzoxazoles and Benzimidazoles related to UK-1. Bioorg. Med. Chem., (10), 3997–4004.

Kern, J. T., Thomas, P. W., & Kerwin, S. M. (2002). The Relationship between Ligand Aggregation and G-quadruplex DNA Selectivity in a Series of 3,4,9,10-Perylenetetracarboxylic Acid Diimides. Biochemistry, (41), 11379–11389.

Kern, J. T., & Kerwin, S. M. (2002). The Aggregation and G-Quadruplex DNA Selectivity of Charged 3,4,9,10-perylenetetracarboxylic Acid Diimides. Bioorg. Med. Chem. Lett., (12), 3395–3398.

Nadipuram, A. K., David, W. M., Kumar, D., & Kerwin, S. M. (2002). Synthesis and Thermolysis of Heterocyclic 3-Aza-3-ene-1,5-diynes. Org. Lett., (4), 4543–4546.

Fletcher, T., Cathers, B., Ravikumar, K. S., Mamiya, B. M., & Kerwin, S. M. (2001). Inhibition of Human Telomerase by 7-Deaza-2’-deoxyguanosine Nucleoside Triphosphate Analogs:  Potent Inhibition by  6-Thio-7-deaza-2’-deoxyguanosine 5’-Triphosphate (TDG-TP). Bioorg. Chem., (29), 36–55.

Kumar, D., Kanz, B., Mamiya, B. M., & Kerwin, S. M. (2001). Synthesis of a Phosphoramide Prodrug of 6-Thio-7-deaza-2’-deoxyguanosine (TDG):  A Regioselective Phosphorylation. Tetrahedron Lett., (42), 565–567.

McPhee, M. M., & Kerwin, S. M. (2001). Synthesis, DNA Cleavage, and Cytotoxicity of a Series of Bis(propargylic) Sulfone Crown Ethers. Bioorg. Med. Chem., (9), 2809–2818.

Reyzer, M. L., Brodbelt, J. S., Kumar, D., & Kerwin, S. M. (2001). Evaluation of Complexation of Metal Mediated DNA Binding Drugs to Oligonucleotides via Electrospray Ionization Mass Spectrometry. Nucl. Acids Res., (29), u9–u20.

Kerwin, S. M., Sun, D., Kern, J. T., Rangan, A., & Thomas, P. W. (2001). G-Quadruplex DNA Binding by a Series of Carbocyanine Dyes. Bioorg. Med. Chem. Lett., (11), 2411–2414.

Kumar, D., David, W. M., & Kerwin, S. M. (2001). N-Propargyl-2-alkynylbenzothiazolium Aza-enediynes: Role of the 2-Alkynylbenzothiazolium Functionality in DNA Cleavage. Bioorg. Med. Chem. Lett., (11), 2971–2974.

Kerwin, S. M., David, W. M., Salazar, M., Tuntiwechapikul, W., & Tuesuwan, B. (2001). DNA Cleavge Chemistry of 1-Methyl-2-phenylethynyl-3-(prop-2-ynyl)-3H-benzoimidazolium Salts. Abstracts of the Papers of the American Chemical Society, (222), MEDI-146.

Kerwin, S. M., Thomas, P. W., Kern, J. T., Ravikumar, K. S., & Chen, G. (2001). The G-quadruplex DNA Binding Selectivity of N,N’-bis(3-morpholin-4-yl-propyl)-3,4,9,10-perylene Tetracarboxylic Acid Diimide is pH Dependent and Mediated by Ligand Aggregation. Abstracts of the Papers of the American Chemical Society, (222), MEDI-142.

Tunitiwechapikul, W., David, W. M., Tuesuwan, B., Salazar, M., & Kerwin, S. M. (2001). Novel Cytosine-selective DNA Alkylation by an Aza-enediyne: Sequence Specificity Studies and Proposed Mechanisms. Abstracts of the Papers of the American Chemical Society, (222), MEDI-143.

Agyin, J. K., Quada, J., Urrabaz, R., Chapa, M., Chen, S., Luduena, R., … Von Hoff, D. (2001). Novel Analogs of FB642: Design, Synthesis, and In Vitro Antitumor Activity. Clin. Cancer Res., (7), 469.

Fletcher, T. M., Cathers, B. E., Ravikumar, K. S., Mamiya, B. M., & Kerwin, S. M. (2001). Inhibition of Human Telomerase by 7-deaza-2’-deoxyguanosine Nucleoside Triposphate Analogs: Potent Inhibiton by 6-Thio-7-deaza-2’-deoxyguanosiine-5’-triphosphate. Bioorg. Chem., 29, 35–55.

Kumar, D., Kanz, B., Mamiya, B. M., Kerns, J., & Kerwin, S. M. (2001). Synthesis of a Phosphoramidate Pro-Drug of 6-Thio-7-deaza-2’-deoxyguanosine (TDG): a Regioselective Phosphorylation. Tetrahedron Lett, 42, 565–567.

Kerwin, S. M. (2000). G-Quadruplex DNA as a Target for Drug Design. Curr. Pharm. Design, (6), 441–471.

Hurley, L. H., Wheelhouse, R. T., Sun, D., Kerwin, S. M., Salazar, M., Fedoroff, O. Y., … Von Hoff, D. D. (2000). G-Quadruplexes as Targets for Drug Design. Pharmacol. Therap., (85), 141–158.

McPhee, M. M., Kern, J. T., Hoster, B. C., & Kerwin, S. M. (2000). Synthesis, Metal ion Binding, and DNA Cleavage Studies of Propargylic Sulfone-Armed Crown Ethers. Bioorg. Chem., (8), 98–118.

Yu, H., Kwok, Y., Hurley, L. H., & Kerwin, S. M. (2000). Efficient, Mg2+-Dependent Photochemical Cleavage of DNA by the Anticancer Quinobenzoxazine (S)-A-62176. Biochemistry, (38), 10236–10246.

David, w M., Kumar, D., & Kerwin, S. M. (2000). Synthesis of a Heterocyclic Aza-Enediyne and Its DNA Cleavage Properties. Bioorg. Med. Chem. Lett., (10), 2509–2512.

Kerwin, S. M., Mamiya, B., Cathers, B., Fletcher, T., Kern, J. T., & Thomas, P. W. (2000). G-Quadruplex DNA as a Target for Drug Discovery: Design of Telomerase Inhibitors Based on G-Quadruplex DNA Structure and Dynamics. Abstracts of Papers American Chemical Society, (219), MEDI 19.

Kerwin, S. M., & Kumar, D. (2000). Synthesis and DNA Cleavage Studies of Thiazolium and Benzothiazolium Salts. Abstracts of Papers American Chemical Society, (219), MEDI 54.

Kerwin, S. M., & David, W. M. (2000). Heterocyclic Aza-variants of Enediynes: Potent DNA Cleavage Agents with Promising Antitumor Activity. Abstracts of Papers American Chemical Society, (219), MEDI 55.

Kerwin, S. M., & Kern, J. T. (2000). Minor groove width and sequence recognition. Abstracts of Papers of the American Chemical Society, (21), MEDI-214.

Kerwin, S. M., Ravikumar, K. S., Miller, D., & Robertus, J. (2000). Structure-based Design of Ricin Inhibitors. Abstracts of Papers of the American Chemical Society, (219), MEDI 291.

Kerwin, S. M., Kumar, D., & David, W. M. (2000). Aza-variants of the Bergman and Myers Cyclizations: Application to Anticancer Drug Discovery. Abstracts of Papers of the American Chemical Society, (219), MEDI 308.

Kerwin, S. M., Kern, J. T., & Thomas, W. P. (2000). G-Quadruplex DNA Ligands:  Effects of Binding Selectivity and Facilitation of G-Quadruplex DNA Formation on Telomerase Inhibition and Cancer Cell Cytotoxicity. Cancer Detect. Prevent., (24), S-30.

Kerwin, S. M., Reynolds, M., & Kumar, D. (2000). Synthesis and Metallo-regulated DNA Binding of Aza-analogs of the Bis(benzoxaole) Anticancer Natural Product UK-1. Abstracts of the Papers of the American Chemical Society, (220), MEDI-33.

Kerwin, S. M. (2000). Review of “Nucleic Acids: Structures, Properties, and Functions.” J. Med. Chem.

Kerwin, S. M. (2000, November 1). Nucleic Acids:  Structures, Properties, and Functions By Victor A. Bloomfield, Donald M. Crothers, and Ignacio Tinoco, Jr., with contributions from John E. Hearst, David E. Wemmer, Peter A. Kollman, and Douglas H. Turner. University Science Books, Sausalito, CA. 2000. ix + 794 pp. 17 × 25 cm. ISBN 0-935702-49-0. $85.00. Journal of Medicinal Chemistry. American Chemical Society (ACS). https://doi.org/10.1021/jm000396p

Yu, H., Kwok, Y., Hurley, L. H., & Kerwin, S. M. (2000). Efficient, Mg2+-Dependent Photochemical DNA Cleavage by the Antitumor Quinobenzoxazine (S)-A-62176. Biochemistry, 39(33), 10236–10246. https://doi.org/10.1021/bi001103x

Reynolds, M. B., Deluca, M. R., & Kerwin, S. M. (1999). The Novel Bis(benzoxazole) Cytotoxic Natural Product UK-1 is a Magnesium Ion-Dependent DNA Binding Agent and Inhibitor of Human Topoisomerase II. Bioorg. Chem., (27), 326–337.

Deluca, M. R., Taraporewala, I., & Kerwin, S. M. (1999). The Conversion of Mixed N,O-Diacylated Aminophenols to 2-Substituted Benzoxazoles. Heterocycles, (51), 979–982.

Fedoroff, O. Y., Salazar, M., Han, H., Chemeris, V. V., Kerwin, S. M., & Hurley, L. H. (1998). NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA. Biochemistry, (36), 12367–12374.

Zeng, Q. P., Kwok, Y., Kerwin, S. M., Mangold, G., & Hurley, L. H. (1998). Design of New Topoisomerase II Inhibitors Based upon a Quinobenzoxazine Self-Assembly Model. J. Med. Chem., (41), 4273–4278.

McPhee, M. M., Kern, J. T., & Kerwin, S. M. (1998). Synthesis, Metal Ion Binding And DNA Cleavage Of Pendent Crown Ether Propargylic Sulfones As Anticancer Agents. Abstracts of Papers American Chemical Society, (215), MEDI 162.

Fedorov, O. Y., Salazar, M., Kerwin, S. M., Han, H., & Hurley, L. H. (1998). High-Field NMR Studies of G-Quadruplex Binding by a Telomerase-Inhibiting Compound. Proceedings American Association for Cancer Research Annual Meeting, (39), 305.

Cathers, B. E., Mamiya, B., Hurley, L. H., & Kerwin, S. M. (1998). On the Mechanism of Telomerase Inhibition by 6-thio-7-deaza-2’-deoxyguanosine Triphosphate. Abstracts of Paper American Chemical Society, (216), MEDI 334.

Shi, D.-F., Scott, B. O., Winchester, R., Kerwin, S. M., Mangold, G., Wheelhouse, R. T., & Hurley, L. H. (1998). Design, Synthesis and Evaluation of New Platinum Chemotherapeutic Agents. Abstracts of Paper American Chemical Society, (216), MEDI 335.

David, W. M., & Kerwin, S. M. (1997). Synthesis and Thermal Rearrangement of C,N-Dialkynyl Imines: A Potential Aza-Bergman Route to 2,5-Didehydropyridine. J. Am. Chem. Soc., (119), 1464–1465.

Deluca, M. R., & Kerwin, S. M. (1997). The para-Toluenesulfonic Acid-Promoted Synthesis of 2-Substituted Benzoxazoles and Benzimidazoles from Diacylated Precursors. Tetrahedron, (53), 457–464.

Deluca, M. R., & Kerwin, S. M. (1997). Total Synthesis of the Novel Cytotoxic Bis(benzoxazole) Natural Product UK-1. Tetrahedron Lett., (38), 199–202.

Sun, D., Thompson, B., Cathers, B. E., Salazar, M., Kerwin, S. M., Trent, J. O., … Hurley, L. H. (1997). Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound. J. Med. Chem., (40), 2113–2116.

Kerwin, S. M., & McPhee, M. M. (1997). Synthesis, Metal Ion Binding, and DNA Cleavage Studies of Bis(propargylic) Sulfone Crown Ethers. Abstracts of Papers American Chemical Society, (211), MEDI 217.

Kerwin, S. M., Deluca, M. R., & Kwok, Y. (1997). The Novel Bis(benzoxazole) Cytotoxic Natural Product UK-1 is a Magnesium Ion-Dependent DNA Binding Agent and Inhibitor of Human Topoisomerase II. Abstracts of Papers American Chemical Society, (213), MEDI 216.

Kerwin, S. M., & David, W. M. (1997). Complementary routes to (E)- and (Z)-tetrasubstituted beta-alkynyl acrylonitriles. Abstracts of Papers American Chemical Society, (213), ORGN-514.

Zeng, Q., Kwok, Y., Kerwin, S. M., & Hurley, L. H. (1997). Template Directed Design and Development of New Quinobenzoxazine Analogs as Anti-Cancer Agents. Abstracts of Papers American Chemical Society, (213), MEDI 218.

Yu, H. T., Hurley, L. H., & Kerwin, S. M. (1996). Evidence for the Formation of 2:2 Drug–Mg2+ Dimers in Solution and for the Formation of Dimeric DNA Complexes on DNA from the DNA-Accelerated Photochemical Reaction of Antineoplastic Quinobenzoxazines. J. Am. Chem. Soc., (118), 7040–7048.

McPhee, M. M., & Kerwin, S. M. (1996). Synthesis and Metal Ion Binding Studies of Enediyne-Containing Crown Ethers. J. Org. Chem., (61), 9385–9393.

Salazar, M., Thompson, B. D., Kerwin, S. M., & Hurley, L. H. (1996). Thermally Induced DNA/RNA Hybrid to G-Tetraplex Transitions: Possible Implications for Telomere Synthesis by Telomerase. Biochemistry, (35), 16011–16115.

Salazar, M., Thompson, B. D., Kerwin, S. M., & Hurley, L. H. (1996). Unwinding of Telomeric Hybrids is Facilitated by G-Quartet Formation. Ann. Oncol., (7), A242.

Kerwin, S. M., & David, W. (1996). The Aza-Bergman Cyclization Route to 2,5-Didehydropyridines. Abstracts of Papers American Chemical Society, (211), ORGN 66.

Watts, C. R., Kerwin, S. M., Kenyon, G. L., Kuntz, I. D., & Kallick, D. A. (1995). Rationally Designed N,N’-bis[(N-p-guanidinobenzyl-N-methyl)amino-carbonyl]1,3-diaminobenzene, “BigBen,” Binds to the Minor Groove of d(CGCGAATTCGCG)2 as Determined by Two-Dimensional Nuclear Magnetic Resonance Spectroscopy. J. Am. Chem. Soc., (117), 9941–9950.

Fan, J. Y., Sun, H., Kerwin, S. M., & Hurley, L. H. (1995). The Self-Assembly of a Quinobenzoxazine–Mg2+ Complex on DNA:  A New Paradigm for the Structure of a Drug-DNA Complex and Implications for the Structure of the Quinolone Bacterial Gyrase–DNA Complex. J. Med. Chem., (38), 408–424.

Salazar, M., Kerwin, S. M., & Hurley, L. H. (1995). Telomeric DNA:RNA Hybrid Duplexes Can Coexist in a Hybrid–DNA Tetraplex Equilibrium that is Temperature and Cation Dependent. Biophys. J., (68), A6.

Watts, C. R., Kerwin, S. M., Kenyon, G. L., Kuntz, I. D., & Kallick, D. A. (1995). Rationally Designed N,N’-Bis(N-p-guanidinobenzyl-N-methyl)aminocarbonyl)1,3-diaminobenzene, “BIGBEN,” Binds to the Minor Groove of d(CGCGAATTCGCG)-2 as Determined by Two-Dimensional Nuclear Magnetic Resonance Spectroscopy. J. Cell. Biochem., 80.

Yu, H., Hurley, L. H., & Kerwin, S. M. (1995). The Quinolones/Quinobenzoxazines form 2:2 Mg-2+-Drug Complexes on DNA in the Presence of Gyrase/Topoisomerase II: Photochemical Evidence. Abstracts of Papers American Chemical Society, (209), MEDI 40.

Fan, J., Kwok, Y., Kerwin, S. M., & Hurley, L. H. (1995). The Quinolones/Quinobenzoxazines form 2:2 Mg2+–Drug Complexes on DNA:  Photochemical Evidence. Abstracts of Papers American Chemical Society, (209), MEDI 66.

Kerwin, S. M. (1995). Macromolecular Visualization in Medicinal Chemistry. J. Pharm. Ed., (99), 82S.

Kerwin, S. M. (1994). Synthesis of a DNA-cleaving bis(propargylic) sulfone crown ether. Tetrahedron Letters, 35(7), 1023–1026. https://doi.org/10.1016/s0040-4039(00)79955-2

Kerwin, S. M. (1994). Computer-Assisted Macromolecular Visualization in Medicinal Chemistry. J. Pharm. Ed., (58), 99s.

Mujeeb, A., Kerwin, S. M., Kenyon, G. L., & James, T. L. (1993). Solution Structure of a Conserved Sequence from the HIV-1 Genome:  Restrained Molecular Dynamics Simulation with Distance and Torsion Angle Restraints Derived from 2D NMR Spectra. Biochemistry, (32), 13419–13431.

Mujeeb, A., Kerwin, S. M., Egan, W., Kenyon, G. L., & James, T. L. (1993). A Highly Conserved Sequence in HIV-1 Genome:  Solution Structure By NMR and Restrained Molecular Dynamics. J. Cell. Biochem., 267.

Mujeeb, A., Kerwin, S. M., Egan, W., Kenyon, G. L., & James, T. L. (1992). A Potential Gene Target in HIV-1:  Rational, Selection of a Conserved Sequence, and Determination of NMR Distance and Torsion Angle Constraints. Biochemistry, (31), 9325–9338.

Kerwin, S. M., & Heathcock, C. H. (1992). Remote Oxidation of Perhydrophenanthrenes by Template-Directed Hydrogen Atom Abstraction. The Journal of Organic Chemistry, 57(14), 4005–4013. https://doi.org/10.1021/jo00040a050

Kerwin, S. M., Kuntz, I. D., & Kenyon, G. L. (1991). The Design of a DNA Binding Compound Using an Automated Procedure for Screening Potential Ligands. Med. Chem, (1), 361–369.

Kerwin, S. M., & Heathcock, C. H. (1988). Commentary on “Albomitomycin A and Isomitomycin A:  Products of Novel Intramolecular Rearrangement of Mitomycin A.  Total Synthesis of (+/-) Mitomycins via Isomitomycin A.” Chemtracts Organic Chem., (1), 156–158.

Kerwin, S. M., & Heathcock, C. H. (1988). Commentary on “Methylaluminum Bis(2,6-di-tert-butyl-4-methylphenoxide) as a Protecting Group for Multifunctional Molecules: Synthetic Utility in Selective Carbonyl Reductions.” Chemtracts Organic Chem., (1), 313–316.

Kerwin, S. M., & Heathcock, C. H. (1988). Commentary on “A Concise Route to the Calicheamicin-Esperamicin Series:  The Crystal Structure of a Core Subunit.” Chemtracts Organic Chem., (2), 21–23.

Kerwin, S. M., Paul, A. G., & Heathcock, C. H. (1987). Quassinoid Synthesis. 2. Preparation of a Tetracyclic Intermediate Possessing the Bruceantin Tetrahydrofuran Ring. J. Org. Chem., (52), 1686–1695.